40371-52-6Relevant articles and documents
Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides
Chandrika, Nishad Thamban,Green, Keith D.,Houghton, Jacob L.,Garneau-Tsodikova, Sylvie
supporting information, p. 1134 - 1139 (2015/11/24)
Despite issues with oto/nephrotoxicity and bacterial resistance, aminoglycosides (AGs) remain an effective and widely used class of antibacterial agents. For decades now, efforts toward the development of novel AGs with potential to overcome some of these
Design of novel antibiotics that bind to the ribosomal acyltransfer site
Haddad, Jalal,Kotra, Lakshmi P.,Llano-Sotelo, Beatriz,Kim, Choonkeun,Azucena Jr., Eduardo F.,Liu, Meizheng,Vakulenko, Sergei B.,Chow, Christine S.,Mobashery, Shahriar
, p. 3229 - 3237 (2007/10/03)
The structure of neamine bound to the A site of the bacterial ribosomal RNA was used in the design of novel aminoglycosides. The design took into account stereo and electronic contributions to interactions between RNA and aminoglycosides, as well as a ran