405-09-4

Basic information

• Product Name: 2-FLUORO-4-METHOXYBENZYL ALCOHOL
• Synonyms: 2-FLUORO-4-METHOXYBENZYL ALCOHOL;RARECHEM AL BD 0456;2-Fluoro-4-methoxybenzyl alcohol 99%;2-Fluoro-4-methoxybenzylalcohol99%;(2-fluoro-4-Methoxyphenyl)Methanol;3-Fluoro-4-(hydroxymethyl)anisole, 2-Fluoro-p-anisyl alcohol, (2-Fluoro-4-methoxyphenyl)methanol
• CAS NO: 405-09-4
• Molecular Formula: C₈H₉FO₂
• Molecular Weight: 156.15
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohols;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds
• Mol File: 405-09-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 233℃
• Flash Point: 115℃
• Appearance: /
• Density: 1.187
• Vapor Pressure: 0.0323mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: 2-8°C
• PKA: 13.95±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-4-METHOXYBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4-METHOXYBENZYL ALCOHOL(405-09-4)
• EPA Substance Registry System: 2-FLUORO-4-METHOXYBENZYL ALCOHOL(405-09-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 405-09-4(Hazardous Substances Data)

Usage

General Description

2-Fluoro-4-methoxybenzyl alcohol is a chemical compound with the molecular formula C8H9FO2. It is a colorless liquid with a molecular weight of 154.15 g/mol. 2-Fluoro-4-methoxybenzyl alcohol is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and pharmaceutical compounds. It is also used as a starting material for the preparation of other organic compounds. Additionally, 2-Fluoro-4-methoxybenzyl alcohol has been studied for its potential biological and pharmacological properties, including its antimicrobial and anti-inflammatory activities. Overall, this chemical compound has a wide range of applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C8H9FO2/c1-11-7-3-2-6(5-10)8(9)4-7/h2-4,10H,5H2,1H3

Upstream product

• 394-42-3 2-fluoro-4-methoxy-benzoic acid 
• 128272-26-4 [13C₂, D₇]2-(2-fluoro-4-methoxyphenyl)propan-2-ol 
• 74457-86-6 1-(2-fluoro-4-methoxyphenyl)-1-ethanone 
• 456-49-5 1-fluoro-3-methoxybenzene 
• 114635-97-1 3-<(dimethyl-tert-butylsilyl)oxy>fluorobenzene 
• 348-27-6 2-fluoro-4-hydroxybenzaldehyde 
• 372-20-3 3-fluorophenol 
• 331-64-6 2-fluoro-4-methoxy-benzaldehyde 

Downstream Products

• 54788-19-1 2-fluoro-4-methoxybenzyl bromide 
• 331-64-6 2-fluoro-4-methoxy-benzaldehyde 
• 78709-81-6 2-fluoro-L-tyrosine 
• 937783-85-2 (2-fluoro-4-methoxyphenyl)methanamine hydrochloride 
• 937783-84-1 di-tert-butyl [2-fluoro-4-methoxybenzylamino]dicarboxylate 
• 331-63-5 1-(chloromethyl)-2-fluoro-4-methoxybenzene 

Relevant articles and documents

Unusual Kinetic Profiles for Lewis Base-Catalyzed Sulfenocyclization of ortho -Geranylphenols in Hexafluoroisopropyl Alcohol

The kinetic behavior of the Lewis base-catalyzed sulfenocyclization of polyenes in hexafluoroisopropyl alcohol (HFIP) was explored. The rate of reaction is not dependent on the electronic properties of the terminal nucleophile, suggesting that this captur

PHARMACEUTICAL COMPOSITION COMPRISING A PYRAZOLE-O-GLUCOSIDE DERIVATIVE

The invention relates toa pharmaceutical composition comprising a pyrazole-O-glucoside derivative selected from the group of compounds (1) to (29) according to claim 1 in combination with at least one second therapeutic agent which is suitable in the trea

Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents

Toxoplasma gondii is an opportunistic pathogen responsible for toxoplasmosis. T. gondii is a purine auxotroph incapable of de novo purine biosynthesis and depends on salvage pathways for its purine requirements. Adenosine kinase (EC.2.7.1.20) is the major enzyme in the salvage of purines in these parasites. 6-Benzylthioinosine and analogues were established as "subversive substrates" for the T. gondii, but not for the human adenosine kinase. Therefore, these compounds act as selective anti-toxoplasma agents. In the present study, a series of N6-benzyladenosine analogues were synthesized from 6-chloropurine riboside with substituted benzylamines via solution phase parallel synthesis. These N6-benzyladenosine analogues were evaluated for their binding affinity to purified T. gondii adenosine kinase. Furthermore, the anti-toxoplasma efficacy and host toxicity of these compounds were tested in cell culture. Certain substituents on the aromatic ring improved binding affinity to T. gondii adenosine kinase when compared to the unsubstituted N6-benzyladenosine. Similarly, varying the type and position of the substituents on the aromatic ring led to different degrees of potency and selectivity as anti-toxoplasma agents. Among the synthesized analogues, N6-(2,4-dimethoxybenzyl)adenosine exhibited the most favorable anti-toxoplasma activity without host toxicity. The binding mode of the synthesized N6-benzyladenosine analogues were characterized to illustrate the role of additional hydrophobic effect and van der Waals interaction within an active site of T. gondii adenosine kinase by induced fit molecular modeling.