40524-62-7

Basic information

• Product Name: 2-Propen-1-one, 1-(2-methoxyphenyl)-3-phenyl-, (2E)-
• CAS NO: 40524-62-7
• Molecular Formula: C16H14O2
• Molecular Weight: 238.286
• Mol File: 40524-62-7.mol
• Article Data: 52

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(2-methoxyphenyl)-3-phenyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(2-methoxyphenyl)-3-phenyl-, (2E)-(40524-62-7)
• EPA Substance Registry System: 2-Propen-1-one, 1-(2-methoxyphenyl)-3-phenyl-, (2E)-(40524-62-7)

Safety Data

• Hazardous Substances Data: 40524-62-7(Hazardous Substances Data)

Upstream product

• 102-92-1 cinnamoyl chloride 
• 100-66-3 methoxybenzene 
• 130824-68-9 1-((E)-1,1-Dimethoxy-3-phenyl-allyl)-2-methoxy-benzene 
• 14371-10-9 (E)-3-phenylpropenal 
• 106-94-5 propyl bromide 
• 31600-86-9 2-methoxyphenyllithium 
• 98-86-2 acetophenone 
• 135-02-4 ortho-anisaldehyde 
• 6783-05-7 trans-2-phenylvinylboronic acid 
• 536-74-3 phenylacetylene 
• 118-93-4 o-hydroxyacetophenone 
• 130824-65-6 (Z)-2,7-Dimethoxychalcone 
• 41126-22-1 1-(2-methoxyphenyl)-3-phenylpropane-1,3-dione 
• 606-45-1 2-methoxybenzoic acid methyl ester 

Downstream Products

• 141885-68-9 (2-Methoxy-phenyl)-(2,4,5-triphenyl-3,4-dihydro-2H-pyrazol-3-yl)-methanone 
• 60857-45-6 (2-methoxyphenyl)(3-phenyloxiran-2-yl)methanone 
• 883448-62-2 2-phenyl-6-(2-hydroxyphenyl)-4-phenylphosphinine 
• 92208-78-1 (2,3–diphenylcyclopropyl)(2–methoxyphenyl)methanone 

Relevant articles and documents

Palladium-Catalyzed Synthesis of α-Methyl Ketones from Allylic Alcohols and Methanol

One-pot synthesis of α-methyl ketones starting from 1,3-diaryl propenols or 1-aryl propenols and methanol as a C1 source is demonstrated. This one-pot isomerization-methylation is catalyzed by commercially available Pd(OAc)2 with H2O as the only by-product. Mechanistic studies and deuterium labelling experiments indicate the involvement of isomerization of allyl alcohol followed by methylation through a hydrogen-borrowing pathway in these isomerization-methylation reactions.

A new method for the synthesis of chalcone derivatives promoted by PPh3/I2under non-alkaline conditions

A straightforward and general method has been developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in the presence of PPh3/I2 in 1,4-dioxane under reflux temperatures. With the condensation of the aromatic ketone and aldehyde occurring at non-strongly alkaline conditions, our proposed method significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions.

Organo-catalyzed Michael addition of 2-fluoro-2-arylacetonitriles

An efficient synthesis of a variety of 2-arylacetonitriles containing a fluorinated stereogenic center through organo-catalyzed Michael addition reaction of 2-fluoro-2-arylacetonitriles has been developed. This protocol uses a cheap organocatalyst (DBU) and has a broad substrate scope: α, β-unsaturated ketones, esters, nitriles and sulfones were all successfully reacted. Importantly, water proved to be a good solvent for this reaction.