4061-29-4

Basic information

• Product Name: 2-(diethylamino)-1-phenylethanone
• Synonyms: 2-(Diethylamino)-1-phenylethanone; ethanone, 2-(diethylamino)-1-phenyl-
• CAS NO: 4061-29-4
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.2695
• Mol File: 4061-29-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 280.5°C at 760 mmHg
• Flash Point: 93.8°C
• Density: 0.984g/cm³
• Vapor Pressure: 0.00377mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: 2-(diethylamino)-1-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(diethylamino)-1-phenylethanone(4061-29-4)
• EPA Substance Registry System: 2-(diethylamino)-1-phenylethanone(4061-29-4)

Safety Data

• Hazardous Substances Data: 4061-29-4(Hazardous Substances Data)

Usage

General Description

2-(diethylamino)-1-phenylethanone, also known as Amfepramone, is a chemical compound that is commonly used as an appetite suppressant in the treatment of obesity. It acts as a central nervous system stimulant and has similar effects to amphetamines. The chemical works by increasing the release of norepinephrine and dopamine in the brain, which helps to reduce appetite and promote weight loss. It is often prescribed for short-term use in combination with a reduced-calorie diet and exercise. However, it can also have potential side effects such as increased heart rate, high blood pressure, and insomnia, and in some cases, it may be habit-forming. Therefore, it should only be used under the guidance of a healthcare professional.

Upstream product

• 532-27-4 1-chloroacetophenone 
• 109-89-7 diethylamine 
• 136559-54-1 N,N-diethyl-1,1-dimethyl-1-((1-phenylvinyl)oxy)silanamine 
• 6274-12-0 diethylamine hydrobromide 
• 70-11-1 α-bromoacetophenone 
• 57589-13-6 (N,N-Diethylaminomethyl)tri-n-butylzinn 
• 98-88-4 benzoyl chloride 

Downstream Products

• 7150-08-5 2-(diethylamino)-1-phenylethanone-methyl iodide 
• 135357-93-6 (R)-(-)-2-(diethylamino)-1-(phenyl)ethanol 
• 22141-59-9 4-Diethylamino-2-methyl-3-phenyl-buten-⁽²⁾-ol-⁽¹⁾ 
• 53915-51-8 4-nitro-benzoic acid-(2-diethylamino-1-phenyl-ethyl ester) 
• 83593-62-8 (S)-2-N,N-diethylamino-1-phenylethanol 
• 4249-64-3 2-diethylamino-1-phenyl-1-ethanol 
• 22500-26-1 N,N-diethyl-2-phenylprop-2-en-1-amine 
• 90-84-6 amfepramone 
• 5554-71-2 1-diethylamino-2-phenyl-butan-2-ol 
• 955951-65-2 1,4-Bis-diethylamino-2,3-diphenyl-butane-2,3-diol 
• 34906-86-0 N,N-diethyl-2-oxo-2-phenylacetamide 
• 128592-68-7 N,N‐diethyl‐2‐oxo‐2‐phenylethanethioamide 
• 65-85-0 benzoic acid 
• 28608-66-4 Butyl-[2-diethylamino-1-phenyl-eth-(Z)-ylidene]-amine 

Relevant articles and documents

Flexible stereoselective functionalizations of ketones through umpolung with hypervalent iodine reagents

The functionalization of carbonyl compounds in the α-position has gathered much attention as a synthetic route because of the wide biological importance of such products. Through polarity reversal, or "umpolung", we show here that typical nucleophiles, such as oxygen, nitrogen, and even carbon nucleophiles, can be used for addition reactions after tethering them to enol ethers. Our findings allow novel retrosynthetic planning and rapid assembly of structures previously accessible only by multistep sequences. A Nu approach: An efficient α-functionalization of ketones with a range of simple and useful nucleophiles is possible by using hypervalent iodine reagents (see scheme; Nu′ can be the Nu itself or a protected form of this nucleophile group).

Asymmetric synthesis of β-dialkylamino alcohols by transfer hydrogenation of α-dialkylamino ketones

Transfer hydrogenation of representative aryl and heteroaryl dialkylaminomethyl ketones with formic acid-triethylamine, catalyzed by RuCl[(R,R)-TsDPEN](η-p-cymene), produces the corresponding β-dialkylamino alcohols, 97-99% ee, in 50-73% yields. Asymmetric synthesis of (R)-macromerine, 98% ee, the cactus Coryphantha macromeris alkaloid, is also described.

Boranes in Synthesis. 2. Asymmetric Synthesis of β-Amino Alcohols. A Facile Conversion of 2-Amino Acetophenones to the Corresponding β-Amino Alcohols in High Enantiomeric Purity

The asymmetric reduction of 2-amino acetophenones with Ipc2BH or Ipc2BCl at -78 deg C, yields the corresponding β-amino alcohols in good to excellent yields.Although only modest (12-45percent ee) enantiomeric excesses were obtained with Ipc2BH, 75-99perce