90-84-6

Basic information

• Product Name: DIETHYLPROPION
• Synonyms: 1-Phenyl-2-diethylamino-1-propanone;2-(diethylamino)-1-phenyl-1-propanon;2-(Diethylamino)-1-phenyl-1-propanone;2-(diethylamino)-propiophenon;2-(diethylamino)propiophenone;2-(Diethylaminopropio)phenone;2-diethylamino-propiophenon;2-diethylaminopropiophenone
• CAS NO: 90-84-6
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.3
• EINECS: 202-019-1
• Mol File: 90-84-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 292℃
• Flash Point: 95℃
• Appearance: /
• Density: 0.972
• Refractive Index: 1.5175 (estimate)
• PKA: 8.49±0.25(Predicted)
• CAS DataBase Reference: DIETHYLPROPION(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYLPROPION(90-84-6)
• EPA Substance Registry System: DIETHYLPROPION(90-84-6)

Safety Data

• Hazardous Substances Data: 90-84-6(Hazardous Substances Data)

Usage

Description

DIETHYLPROPION, also known as an aromatic ketone, is a central stimulant and indirect-acting sympathomimetic. It is an appetite depressant and is used as the hydrochloride for short-term management of obesity.

Uses

Used in Pharmaceutical Industry:
DIETHYLPROPION is used as an appetite depressant for the short-term management of obesity. It stimulates the secretion of norepinephrine, which helps in reducing appetite and promoting weight loss.
Used in Weight Loss Supplements:
DIETHYLPROPION is used as a weight loss supplement to help individuals control their appetite and lose weight more effectively.
Brand Names:
Some of the brand names for DIETHYLPROPION include Adiposan, Adipyn, Alipid, Amfepromone, Apisate, Bonumin, Brenalalit, Brendalit, Controlgras, D.i.p.n, Delgamer, Deramix, Dietec, Dietil Retard, Dietil-Retard, Lineal-Plus, Lineal-Rivo, Lineal-Valeas, Linea-Valeas, Lipomin, Liposlim, Menutil, Moderatan Diffucap, Nobensin-75, Nobensine, Nobesine-25, Nulobes, Perfamone, Prefamone, Redicres, Regenon Retard, Regibon, Sinapet, Slim-Plus, Super Emegrin, T-712, Tenuate Dospan, and Tenucap.

World Health Organization (WHO)

Amfepramone, a phenethylamine derivative introduced in 1957, is controlled under Schedule IV of the 1971 Convention on Psychotropic Substances. It remains available in many other countries with highly evolved drug regulatory authorities as an aid to weight reduction.(Reference: (UNCPS4) United Nations Convention on Psychotropic Substances (IV), , , 1971)

InChI:InChI=1S/C13H19NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11H,4-5H2,1-3H3

Upstream product

• 637-50-3 1-phenylpropene 
• 109-89-7 diethylamine 
• 37471-46-8 1-phenyl-1-trimethylsiloxypropene 
• 5265-18-9 (+/-)-cathinone 
• 873-66-5 1-propenylbenzene 
• 93-55-0 1-phenyl-propan-1-one 
• 660-68-4 diethyl amine hydrochloride 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 108-86-1 bromobenzene 
• 93-54-9 1-Phenyl-1-propanol 
• 4061-29-4 N,N-diethylphenacylamine 

Downstream Products

• 4830-54-0 2-Diethylamino-1-phenyl-propan-1-ol 
• 4830-54-0 2-Diethylamino-1-phenyl-propan-1-ol 

Relevant articles and documents

Electrochemical, Iodine-Mediated α-CH Amination of Ketones by Umpolung of Silyl Enol Ethers

The electrochemical, oxidative Umpolung reaction of silyl enol ethers utilizing simple iodide salts for the synthesis of α-amino ketones is described. The products were isolated in excellent yields of up to 100percent, and various functionalized starting materials were accepted in an undivided electrochemical cell design. Moreover, a sensitivity assessment to ensure an improved reproducibility of the reaction and cyclic voltammetry experiments were performed to postulate a plausible reaction mechanism on their basis.

A five coordination Cu(II) cluster-based MOF and its application in the synthesis of pharmaceuticals: Via sp3 C-H/N-H oxidative coupling

Herein, a copper metal-organic framework, termed as VNU-18, containing penta-coordinated sites was successfully synthesized and fully characterized. This material was demonstrated to be an efficient heterogeneous catalyst for the oxidative C-H activation via N-H bonds. The optimized conditions are applicable for the synthesis of pharmaceuticals constructed by α-amino carbonyl skeletons.

1,3-Dibromo-5,5-dimethylhydantoin (DBH) mediated one-pot syntheses of α-bromo/amino ketones from alkenes in water

α-Bromo ketones are versatile intermediates of high practical utility. Traditional approaches to these compounds are restricted to a relatively hazardous/complex reagent combination, a long reaction time, the use of non-environmentally friendly solvents, or a limited substrate scope. Herein, we describe the development of a new methodology for the preparation of α-bromo ketones from alkenes using 1,3-dibromo-5,5-dimethylhydantoin (DBH) as a bromine source and an oxidant simultaneously. This easy to carry out two-step one-pot protocol proceeds in water and provides high yield of a great variety of α-bromo ketones. Addition of an amine to the intermediate α-bromo ketone further enables the preparation of α-amino ketones in a one-pot sequence.