40865-50-7 Usage
General Description
2,7-Diazaspiro[4.5]decane, also known as tropane, is a bicyclic organic compound with a unique seven-membered ring structure. It is a heterocyclic compound composed of two nitrogen atoms and a spiro carbon ring, which gives it its name. Tropane is commonly found in various plant species, such as in the nightshade family, and it also occurs as a natural product in certain fungi. It has important pharmaceutical applications, serving as the basis for the synthesis of many medicinal compounds, including atropine and cocaine. Tropane derivatives have been studied for their potential use as anticholinergic agents and as treatments for neurological disorders. Additionally, tropane is of interest to synthetic organic chemists due to its complex structure and its potential for the development of novel chemical reactions and synthetic methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 40865-50-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,8,6 and 5 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 40865-50:
(7*4)+(6*0)+(5*8)+(4*6)+(3*5)+(2*5)+(1*0)=117
117 % 10 = 7
So 40865-50-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H16N2/c1-2-8(6-9-4-1)3-5-10-7-8/h9-10H,1-7H2
40865-50-7Relevant articles and documents
Synthesis and differential functionalisation of pyrrolidine and piperidine based spirodiamine scaffolds
Weinberg, Kamil,Stoit, Axel,Kruse, Chris G.,Haddow, Mairi F.,Gallagher, Timothy
, p. 4694 - 4707 (2013/07/04)
The synthesis and differential substitution/protection of a series of spirodiamine scaffolds are described. Methods for selective access to the two mono-N-methyl isomers based on 2,7-diazaspiro[4.5]decane are also described. Key precursors associated with this chemistry are prone to rearrangement and methods for circumventing this issue are reported. While direct mono-carbamoylation (Boc) was not efficient, selective deprotection of doubly Boc-protected derivatives derived from symmetrical diamines provided mono-Boc variants. N-Arylation, exemplified by a series of monosubstituted spirodiamines incorporating the 2-chloro-5-pyridyl moiety, which is a privileged nicotinic agonist substructure, has also been carried out to provide monoarylated secondary and tertiary spirodiamines variants.
