40885-82-3Relevant articles and documents
Distinct CCK-2 receptor conformations associated with β-arrestin-2 recruitment or phospholipase-C activation revealed by a biased antagonist
Magnan, Rémi,Escrieut, Chantal,Gigoux, Véronique,De, Kavita,Clerc, Pascal,Niu, Fan,Azema, Joelle,Masri, Bernard,Cordomi, Arnau,Baltas, Michel,Tikhonova, Irina G.,Fourmy, Daniel
supporting information, p. 2560 - 2573 (2013/03/29)
Seven-transmembrane receptors (7TMRs), also termed G protein-coupled receptors (GPCRs), form the largest class of cell surface membrane receptors, involving several hundred members in the human genome. Nearly 30% of marketed pharmacological agents target
Novel benzodiazepine photoaffinity probe stereoselectively labels a site deep within the membrane-spanning domain of the cholecystokinin receptor
Hadac, Elizabeth M.,Dawson, Eric S.,Darrow, James W.,Sugg, Elizabeth E.,Lybrand, Terry P.,Miller, Laurence J.
, p. 850 - 863 (2007/10/03)
An understanding of the molecular basis of drug action provides opportunities for refinement of drug properties and for development of more potent and selective molecules that act at the same biological target. In this work, we have identified the active
Solid phase synthesis of 6-acylamino-1-alkyl/aryl-4-oxo-1,4- dihydrocinnoline-3-carboxamides
Sereni, Laura,Tató, Marco,Sola, Francesco,Brill, Wolfgang K.-D.
, p. 8561 - 8577 (2007/10/03)
6-Acylmino-1-alkyl/aryl-4-oxo-1,4-dihydrocinnoline-3-carboxamides were synthesized in parallel from 6-nitro-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid. The latter formed amides with amines bound to polystyrene-based resins via acid-labile linkers. N1 an