40888-04-8

Basic information

• Product Name: 3-benzyl-5-chloro-1,3-benzoxazol-2(3H)-one
• Synonyms: 3-benzyl-5-chloro-1,3-benzoxazol-2(3H)-one
• CAS NO: 40888-04-8
• Molecular Weight: 259.692
• Mol File: 40888-04-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-benzyl-5-chloro-1,3-benzoxazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyl-5-chloro-1,3-benzoxazol-2(3H)-one(40888-04-8)
• EPA Substance Registry System: 3-benzyl-5-chloro-1,3-benzoxazol-2(3H)-one(40888-04-8)

Safety Data

• Hazardous Substances Data: 40888-04-8(Hazardous Substances Data)

Upstream product

• 108-88-3 toluene 
• 17200-29-2 5-chloro-benzoxazole 
• 100-39-0 benzyl bromide 
• 95-25-0 5-chloro-2-benzoxazolinone 
• 10468-17-4 N-(3-chlorophenyl)hydroxylamine 
• 32019-34-4 N-[3-chlorophenyl]-α-phenyl nitrone 
• 100-52-7 benzaldehyde 
• 76-02-8 trifluoroacetyl chloride 

Relevant articles and documents

N-benzyl-benzoxazolone compound and synthesis method thereof

The invention provides an N-benzyl-benzoxazolone compound and a synthesis method thereof. Under the condition of sealed air, catalyzed without metal, a benzoxazolone compound directly reacts with a methylbenzene compound to prepare the N-benzyl-benzoxazolone compound. Compared with the prior art, the synthesis method is very simple and convenient, raw materials are easy to obtain, the cost is low, the efficiency is high, the method is suitable for various reaction substrates. Prepared products can be used for clinical drugs and drug intermediates capable of effectively treating diseases.

CsF-Celite catalyzed facile N-alkylation of 2(3H)-benzoxazolones and antimicrobial properties of 2-substituted benzoxazole and 3-substituted-2(3H)- benzoxazolone derivatives

The synthesis and antimicrobial activity studies of a new series of cyclic amine containing benzoxazoles and benzoxazolone-2(3H)-ones derivatives were described. The alkylation of benzoxazolone was carried out using cesium fluoride-Celite. The newly synthesized compounds with the influence of the induction of the cyclic amine moiety in the benzoxazole scaffold have been evaluated with respect to the antibacterial and antifungal activity. The 2-cyclic amine-1,3-benzoxazoles (5a-l), 5-chloro-3-alkyl substituted-1,3- benzoxazol-2(3H)-ones (8a-f), and 3-[3- (cyclic amine)propyl]-1,3-benzoxazol- 2(3H)-ones (9a-f) were synthesized. These derivatives were tested for antibacterial and antifungal activity. Among the compounds tested, 8c and 9f showed moderate to good antibacterial and antifungal activity. Compound 8a showed good antifungal activity. Springer Science+Business Media, LLC 2010.