4093-41-8

Basic information

• Product Name: METHYL 4-(ACETYLAMINO)-2-METHOXY-5-NITR&
• Synonyms: METHYL 4-(ACETYLAMINO)-2-METHOXY-5-NITR&;methyl 4-(acetylamino)-5-nitro-o-anisate;4-Acetamido-2-methoxy-5-nitrobenzoic acid methylester;METHYL 4-(ACETYLAMINO)-2-METHOXY-5-NITRO;5-NITROMETHOPABATE;4-Acetylamino-2-methoxy-5-nitro-benzoic acid methyl ester;Methyl 4-(acetylamino)-2-methoxy-5-nitrobenzoate;methyl 4-acetamido-2-methoxy-5-nitrobenzoate
• CAS NO: 4093-41-8
• Molecular Formula: C₁₁H₁₂N₂O₆
• Molecular Weight: 268.22278
• EINECS: 223-844-3
• Product Categories: Benzene series;C10 to C11;Carbonyl Compounds;Esters
• Mol File: 4093-41-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 171-173 °C(lit.)
• Boiling Point: 506.8°Cat760mmHg
• Flash Point: 260.3°C
• Appearance: /
• Density: 1.366g/cm³
• Vapor Pressure: 2.16E-10mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: METHYL 4-(ACETYLAMINO)-2-METHOXY-5-NITR&(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-(ACETYLAMINO)-2-METHOXY-5-NITR&(4093-41-8)
• EPA Substance Registry System: METHYL 4-(ACETYLAMINO)-2-METHOXY-5-NITR&(4093-41-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 4093-41-8(Hazardous Substances Data)

Usage

General Description

Methyl 4-(acetylamino)-2-methoxy-5-nitrobenzoate is a chemical compound with the molecular formula C11H12N2O6. It is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. METHYL 4-(ACETYLAMINO)-2-METHOXY-5-NITR& is a nitrobenzoate ester, which contains a nitro group and an acetylamino group. It is a white to off-white solid that is sparingly soluble in water. METHYL 4-(ACETYLAMINO)-2-METHOXY-5-NITR& is used in the production of various drugs and pesticides and is also used as a research chemical in the pharmaceutical and agricultural industries.

InChI:InChI=1/C11H12N2O6/c1-6(14)12-8-5-10(18-2)7(11(15)19-3)4-9(8)13(16)17/h4-5H,1-3H3,(H,12,14)

Upstream product

• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 4093-29-2 methyl 4-(acetylamino)-o-anisate 

Downstream Products

• 1219014-66-0 ethyl 4-amino-2-methoxy-5-nitrobenzoate 
• 1219014-67-1 ethyl 4,5-diamino-2-methoxybenzoate 
• 59338-85-1 methyl-4,5-diamino-2-methoxybenzoate 
• 935873-24-8 methyl 4-[acetyl-(3-tert-butoxycarbonylamino-3-methyl-butyl)-amino]-2-methoxy-5-nitro-benzoate 
• 156601-89-7 methyl 4-(N-acetyl-N-methylamino)-2-methoxy-5-nitrobenzoate 
• 59338-84-0 methyl 4-amino-2-methoxy-5-nitrobenzoate 
• 59338-91-9 2-methoxy 4,5-diamino benzoic acid 
• 1027073-25-1 N-[4-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-5-methoxy-2-nitro-phenyl]-N-methyl-acetamide 
• 156601-92-2 N-[5-Methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-N-methyl-acetamide 
• 126436-38-2 2-(4-Amino-3-chloro-2-methoxy-5-nitro-phenyl)-4-methyl-5-pyridin-3-yl-imidazol-1-ol 
• 126436-41-7 2-Chloro-3-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-6-nitro-phenylamine 
• 1026638-96-9 N-[2-Amino-5-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-N-methyl-acetamide 
• 1025879-92-8 N-[2-Amino-5-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide 
• 126436-42-8 2-(4-amino-2-methoxy-5-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole 

Relevant articles and documents

ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I' PATHWAY AND METHODS OF USE THEREOF

The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors

The synthesis and structure-activity relationships (SAR) of Chk1 inhibitors based on a 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one core are described. Specifically, an exploration of the 7 and 8 positions on this previously disclosed core afforded compounds with improved enzymatic and cellular potency.