4113-04-6Relevant articles and documents
Bisaryldiketene derivatives: A new class of selective ligands for c-myc G-quadruplex DNA
Peng, Dan,Tan, Jia-Heng,Chen, Shuo-Bin,Ou, Tian-Miao,Gu, Lian-Quan,Huang, Zhi-Shu
, p. 8235 - 8242 (2010)
A series of bisaryldiketene derivatives were designed and synthesized as a new class of specific G-quadruplex ligands. The ligand-quadruplex interactions were further evaluated by FRET, ITC, and PCR stop assay. In contrast to most of the G-quadruplex ligands reported so far, which comprise an extended aromatic ring, these compounds are neither polycyclic nor macrocyclic, but have a non-aromatic and relative flexible linker between two quinoline moieties enabling the conformation of compounds to be flexible. Our results showed that these bisaryldiketene derivatives could selectively recognize G-quadruplex DNA rather than binding to duplex DNA. Moreover, they showed promising discrimination between different G-quadruplex DNA. The primary binding affinity of ligand M2 for c-myc G-quadruplex DNA was over 200 times larger than that for telomere G-quadruplex DNA.
Oxidation of alcohols to aldehydes with bromoisobutyrate and dimethyl sulfoxide
Wu, Fei-Yue,Chen, Xiao-Hui,Zhou, Hai-Mei,Li, Jia-Qin,Cui, Hai-Lei
supporting information, (2021/09/29)
We have developed an efficient oxidation of primary alcohols to aldehydes with ethyl bromoisobutyrate and dimethyl sulfoxide. Diaryl ketone can also be prepared under this reaction system.
Imidazopyridine-fused [1,3]diazepinones: modulations of positions 2 to 4 and their impacts on the anti-melanoma activity
Ali, Lamiaa M. A.,Baccon-Sollier, Paul Le,Cuq, Pierre,Lichon, Laure,Malki, Yohan,Masurier, Nicolas,Maye, Morgane,Vincent, Laure-Ana?s
, p. 935 - 949 (2020/04/17)
A series of 19 novel pyrido-imidazodiazepinones, with modulations of positions 2, 3 and 4 of the diazepine ring were synthesised and screened for their in vitro cytotoxic activities against two melanoma cell lines (A375 and MDA-MB-435) and for their poten