41135-98-2

Basic information

• Product Name: 14-hydroxymorphine-6-one
• Synonyms: 14-hydroxymorphine-6-one;(5R)-3,14-Dihydroxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-one;(5α)-7,8-Didehydro-4α,5-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one;OxyMorphinone
• CAS NO: 41135-98-2
• Molecular Formula: C₁₇H₁₇NO₄
• Molecular Weight: 317.33646
• EINECS: 255-236-9
• Mol File: 41135-98-2.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 14-hydroxymorphine-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 14-hydroxymorphine-6-one(41135-98-2)
• EPA Substance Registry System: 14-hydroxymorphine-6-one(41135-98-2)

Safety Data

• Hazardous Substances Data: 41135-98-2(Hazardous Substances Data)

Usage

Description

14-hydroxymorphine-6-one, also known as Oxymorphinone, is a pale yellow solid that serves as a major metabolite of Morphine (M652290). It is a significant compound in the field of pharmaceuticals due to its chemical properties and potential applications.

Uses

Used in Pharmaceutical Industry:
14-hydroxymorphine-6-one is used as an intermediate in the synthesis of various pharmaceutical compounds for its role as a metabolite of Morphine. Its chemical properties make it a valuable component in the development of new drugs with potential pain-relieving and therapeutic effects.
Used in Research and Development:
In the field of scientific research, 14-hydroxymorphine-6-one is utilized as a key substance for studying the metabolic pathways of Morphine and understanding its effects on the human body. This knowledge can contribute to the advancement of drug design and the creation of more effective medications.
Used in Quality Control and Analysis:
14-hydroxymorphine-6-one is also employed in the quality control and analysis of Morphine and its derivatives. Its presence in samples can be used to verify the purity and authenticity of these substances, ensuring the safety and efficacy of medications containing Morphine.

Upstream product

• 109440-85-9 4,5α-epoxy-3,8β,14-trihydroxy-17-methyl-morphinan-6-one 
• 508-54-3 14-hydroxycodeinone 
• 1234788-73-8 oxymorphinone-N-oxide hydrochloride 
• 467-04-9 oripavine 
• 23185-97-9 8β,14-dihydroxy-7,8-dihydrocodeinone 
• 115-37-7 thebaine 
• 57-27-2 MORPHIN 

Downstream Products

• 16590-41-3 Naltrexone 
• 20594-83-6 nalbuphine 
• 64643-76-1 4,5α-epoxy-3,14-diacetoxy-6-oxo-17-methylmorphinan 
• 131575-15-0 3-(Benzyloxy)-7,8-didehydro-4,5α-epoxy-14β-methoxy-17-methylmorphinan-6-one 
• 1357076-49-3 3-O-benzyl-14-O-but-2-enyloxymorphinone 
• 26988-26-1 3-O-benzyl-14-hydroxymorphinone 
• 33522-95-1 noroxymorphone 
• 465-65-6 Naloxone 
• 76-41-5 oxymorphone 
• 84116-46-1 7,8-didehydro-4,5α-epoxymorphinan-6-keto-3,14-diol 
• 862190-33-8 6-O-tosyl-14-hydroxy-3-deoxymorphine 
• 3371-56-0 6α-oxymorphol 

Relevant articles and documents

Direct and simple O-demethylation of thebaine to oripavine

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Design and Development of Pd-Catalyzed Aerobic N-Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode

Strategies for the generation of noroxymorphone from 14-hydroxymorphinone are presented. Noroxymorphone is the key intermediate in the synthesis of various opioid antagonists, including naloxone, naltrexone, and nalmefene, as well as mixed agonists-antagonists such as nalbuphine. The transformation requires removal of the N-methyl group from the naturally occurring opiates and double-bond hydrogenation. The pivotal reaction step thereby is an N-methyl oxidation with colloidal palladium(0) as catalyst and pure oxygen as terminal oxidant. The reaction produces a 1,3-oxazolidine intermediate, which can be readily hydrolyzed to the corresponding secondary amine. Different reaction sequences and the use of various phenol protecting groups were explored. The most direct route consumes only H2, O2, and H2O as stoichiometric reagents and produces only H2O as a byproduct. Challenges inherent to gas/liquid reactions with oxygen as oxidant have been addressed by developing a continuous flow process.

PROCESS FOR OBTAINING 3,14-DIACETYLOXYMORPHONE FROM ORIPAVINE

The present invention relates to a new process for obtaining 3,14-diacetyloxymorphone from oripavine, a process to transform the obtained 3,14-diacetyloxymorphone into a noroxymorphone and a process to transform said noroxymorphone into naloxone, naltrexone, nalbuphine, nalfurafine or nalmefene.