4125-45-5

Basic information

• Product Name: Benzene, 2-methoxy-4-(2-propenyl)-1-(2-propenyloxy)-
• CAS NO: 4125-45-5
• Molecular Formula: C13H16O2
• Molecular Weight: 204.269
• Mol File: 4125-45-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzene, 2-methoxy-4-(2-propenyl)-1-(2-propenyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 2-methoxy-4-(2-propenyl)-1-(2-propenyloxy)-(4125-45-5)
• EPA Substance Registry System: Benzene, 2-methoxy-4-(2-propenyl)-1-(2-propenyloxy)-(4125-45-5)

Safety Data

• Hazardous Substances Data: 4125-45-5(Hazardous Substances Data)

Upstream product

• 97-53-0 4-allylguaiacol 
• 591-87-7 Allyl acetate 
• 107-18-6 allyl alcohol 
• 35466-83-2 allyl methyl carbonate 
• 269410-22-2 4-hydroxy-3-methoxyphenylboronic acid pinacol ester 
• 1616917-77-1 2-(4-(allyloxy)-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 106-95-6 allyl bromide 

Downstream Products

• 7799-39-5 2,4-diallyl-6-methoxy-phenol 
• 1365640-34-1 (E,E)-2-methoxy-4,6-di(1-propen-1-yl)phenyl propionate 
• 1365640-32-9 2,4-diallyl-6-methoxyphenyl propionate 
• 97-53-0 4-allylguaiacol 
• 458-36-6 trans-coniferyl aldehyde 

Relevant articles and documents

Antibacterial and antioxidant bio-based networks derived from eugenol using photo-activated thiol-ene reaction

Bio-based networks derived from eugenol and linalool were prepared with an eco-friendly process by photoactivated thiol-ene reactions. Allyl derivative Eugenol, AE, prepared by a nucleophilic substitution was combined with linalool, L, a monoterpene prese

Epoxy (meth) acrylate compounds and pharmaceutical compositions containing curable composition

[Problem] To provide an epoxy (meth)acrylate compound that serves as a material for a protective film that is unlikely to cause migration to an electrically conductive pattern, and a curable composition containing the epoxy (meth)acrylate compound. [Solut

Eugenol derived immunomodulatory molecules against visceral leishmaniasis

Visceral leishmaniasis (VL) is a life threatening infectious disease caused by Leishmania donovani. It leads to the severe immune suppression in the host defense system. Higher cytotoxicity, rigorous side effects and lower therapeutic indexes (TI) of current antileishmanial drugs have created a necessity to develop new molecules with better antileishmanial activity and high TI value. In this study, we have synthesized 36 derivatives of eugenol and screened them for their activity against promastigote and amastigote forms of L. donovani. Among the synthesized derivatives, comp.35 showed better antileishmanial activity against extra cellular promastigotes (IC50- 20.13 ± 0.91 μM) and intracellular amastigotes (EC50-4.25 ± 0.26 μM). The TI value (82.24 ± 3.77) was found to improve by 10–13 fold compared to Amphotericin B and Miltefosine respectively. Treatment with comp.35 (5 μg/ml) enhanced the nitric oxide (NO) generation, iNOS2 mRNA expression (～8 folds increase) and decreased the arginase-1 activity (～4 folds) in L. donovani infected peritoneal macrophages. Comp.35 had also increased the IL-12 (～6 folds) and decreased the IL-10 (～3 folds) mRNA expression and release in vitro. Results of in vivo studies revealed that comp.35 treatment at 25 mg/kg body weight efficiently cleared the hepatic and splenic parasite burden with enhanced Th1 response in L. donovani infected BALB/c mice. Hence, this study clearly represents comp.35, as an immunomodulatory molecule, can induce host protective immune response against visceral leishmaniasis through enhanced NO generation and Th1 response, which are essentials against this deadly disease.