4140-83-4

Basic information

• Product Name: 2-amino-4-chlorobenzenesulphonamide
• Synonyms: 2-amino-4-chlorobenzenesulphonamide;Einecs 223-965-1
• CAS NO: 4140-83-4
• Molecular Formula: C₆H₇ClN₂O₂S
• Molecular Weight: 206.64998
• EINECS: 223-965-1
• Mol File: 4140-83-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 144-146 °C
• Boiling Point: 420°Cat760mmHg
• Flash Point: 207.8°C
• Appearance: /
• Density: 1.558g/cm³
• Vapor Pressure: 2.9E-07mmHg at 25°C
• Refractive Index: 1.637
• PKA: 10.10±0.60(Predicted)
• CAS DataBase Reference: 2-amino-4-chlorobenzenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-chlorobenzenesulphonamide(4140-83-4)
• EPA Substance Registry System: 2-amino-4-chlorobenzenesulphonamide(4140-83-4)

Safety Data

• Hazardous Substances Data: 4140-83-4(Hazardous Substances Data)

Usage

Description

2-amino-4-chlorobenzenesulphonamide is a chemical compound that belongs to the family of benzenesulfonamides. It is a white to slightly yellow crystalline powder that is sparingly soluble in water.
Used in Pharmaceutical Industry:
2-amino-4-chlorobenzenesulphonamide is used as a diuretic and antihypertensive agent for the treatment of medical conditions such as edema and hypertension. It functions by inhibiting the activity of carbonic anhydrase, an enzyme involved in the production of aqueous humor in the eye and the reabsorption of sodium and potassium ions in the kidneys.
Additionally, 2-amino-4-chlorobenzenesulphonamide is used as a potential antiviral and antibacterial agent in the development of medications. However, it requires careful handling due to its potential to cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C6H7ClN2O2S/c7-4-1-2-6(5(8)3-4)12(9,10)11/h1-3H,8H2,(H2,9,10,11)

Upstream product

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Relevant articles and documents

Simple and chemoselective reduction of aromatic nitro compounds to aromatic amines: Reduction with hydriodic acid revisited

Reduction of aromatic nitro compounds to amines with hydriodic acid was reinvestigated. Under a milder non-refluxing condition (at 90°C for 2-4 h), the reduction proceeded efficiently with excellent chemoselectivity without affecting other functional groups including nitrile, ester, halide, carbonyl, amide, sulfonamide, imidazole and methylthio groups.

Hypoglycaemic agents. III.

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