4144-55-2Relevant articles and documents
MODIFIED AMINE LIPIDS
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Page/Page column 160-161; 187, (2020/07/04)
The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.
Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages
Horikawa, Manabu,Tateda, Kazuhiro,Tuzuki, Etsu,Ishii, Yoshikazu,Ueda, Chihiro,Takabatake, Tohru,Miyairi, Shinichi,Yamaguchi, Keizou,Ishiguro, Masaji
, p. 2130 - 2133 (2007/10/03)
The synthesis of the analogs of N-3-oxododecanoyl-l-homoserine lactone (1) and their structure-activity relationship for the apoptotic induction in macrophages, P388D1 cells, are described. It was revealed that the position of the oxo group in the acyl si
Asymmetric hydrogenation method of a ketonic compound and derivative
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, (2008/06/13)
The present invention relates to a process for the asymmetric hydrogenation of a ketonic compound and derivative. The invention relates to the use of optically active metal complexes as catalysts for the asymmetric hydrogenation of a ketonic compound and derivative. The process for the asymmetric hydrogenation of a ketonic compound and derivative is characterized in that the asymmetric hydrogenation of said compound is carried out in the presence of an effective amount of a metal complex comprising as ligand an optically active diphosphine corresponding to one of the following formulae: STR1