4160-51-4

Basic information

• Product Name: 4'-Methoxybutyrophenone
• Synonyms: 4'-METHOXYBUTYROPHENONE, TECH., 93%;4-Methoxyphenylpropyl ketone;4'-Methoxybutyrophenone,93%,tech.;Butyrophenone, 4'-methoxy- (8CI);4'-METHOXYBUTYROPHENONE;4-METHOXYBUTYROPHENONE;1-(4-METHOXYPHENYL)-1-BUTANONE;1-(4-METHOXYPHENYL)BUTAN-1-ONE
• CAS NO: 4160-51-4
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• EINECS: 223-995-5
• Product Categories: Miscellaneous
• Mol File: 4160-51-4.mol
• Article Data: 64

Chemical Properties

• Melting Point: 22 °C
• Boiling Point: 124-128 °C (4 mmHg)
• Flash Point: 124-128°C/4mm
• Appearance: white crystal
• Density: 1.0292 (rough estimate)
• Refractive Index: 1.5378-1.5398
• BRN: 908286
• CAS DataBase Reference: 4'-Methoxybutyrophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Methoxybutyrophenone(4160-51-4)
• EPA Substance Registry System: 4'-Methoxybutyrophenone(4160-51-4)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 4160-51-4(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR YELLOW LIQUID

Upstream product

• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 109-74-0 propyl cyanide 
• 100-66-3 methoxybenzene 
• 69638-92-2 1,2-butyrideneacetate 
• 107-92-6 butyric acid 
• 927-77-5 n-propylmagnesium bromide 
• 123-11-5 4-methoxy-benzaldehyde 
• 24165-60-4 1-(4-methoxyphenyl)but-3-en-1-ol 
• 141-75-3 butyryl chloride 
• 93-04-9 2-Methoxynaphthalene 
• 106-31-0 butanoic acid anhydride 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 22135-50-8 1-(4-(methoxy)phenyl)butan-1-ol 
• 18272-84-9 4-n-butylanisole 

Downstream Products

• 100117-47-3 2-(4-methoxybenzoyl)butanal 
• 881-43-6 2-bromo-1-(4-methoxyphenyl)butan-1-one 
• 31254-25-8 S-<3-(p-Methoxyphenyl)hexen-(2)-yl>isothiuroniumacetat 
• 68432-09-7 4-ethyl-5-(4-methoxy-phenyl)-4,5-dihydro-isoxazol-3-ylamine 
• 82938-11-2 Ethyl 3-p-methoxyphenyl-hex-2-enoate 
• 120553-85-7 (E)-3-(4-Methoxyphenyl)-2-hexenal 
• 38226-52-7 1-(Naphthalene-2-sulfinyl)-2-phenyl-pentan-2-ol 
• 31254-22-5 3-Hydroxy-3-(p-methoxyphenyl)-1-hexen 
• 172988-64-6 ethyl 5-(4-methoxyphenyl)-4-ethyl-2-methyl-3,5-dioxopentanoate 
• 306972-70-3 Dimethyl (4R,5R)-2-(4-methoxyphenyl)-2-propyl-1,3-dioxolane-4,5-dicarboxylate 
• 71526-44-8 1,3-bis(4-methoxyphenyl)-2-ethyl-propane-1,3-dione 
• 97060-29-2 1-(4-methoxyphenyl)-but-2-en-1-one 
• 440368-69-4 2-(cyclohexyl-hydroxy-methyl)-1-(4-methoxy-phenyl)-butan-1-one 
• 440368-70-7 2-(cyclopentyl-hydroxy-methyl)-1-(4-methoxy-phenyl)-butan-1-one 

Relevant articles and documents

Rh-Catalyzed Coupling of Aldehydes with Allylboronates Enables Facile Access to Ketones

We present herein a novel strategy for the preparation of ketones from aldehydes and allylic boronic esters. This reaction involves the allylation of aldehydes with allylic boronic esters and the Rh-catalyzed chain-walking of homoallylic alcohols. The key to this successful development is the protodeboronation of alkenyl borylether intermediate via a tetravalent borate anion species in the presence of KHF2 and MeOH. This approach features mild reaction conditions, broad substrate scope, and excellent functional group tolerance. Mechanistic studies also supported that the tandem allylation and chain-walking process were involved.

Aminophenone compounds as well as preparation method and application thereof

The invention belongs to the technical field of medicinal chemistry, and particularly relates to aminophenone compounds as well as a preparation method and application thereof. The aminophenone compounds provided by the invention have a good inhibition effect on PDE4, also have good bioavailability, can be applied to preparation of drugs for treating PDE4-related diseases, and increase the optionsof drugs for treating PDE4-related diseases; and the effect of a part of the aminophenone compounds is equivalent to the effect of positive drugs, and the aminophenone compounds have good developmentpotential.

AN IMPROVED AND COMMERCIALLY VIABLE PROCESS FOR PREPARATION OF ARYL KETONES

The present disclosure provides a process for preparing an aryl ketone of Formula I, comprising reacting a substituted benzene of Formula II with a carboxylic acid of formula IIIa and/or a carboxylic anhydride of formula IIIb in presence of an alkyl sulfonic acid acting as catalyst cum solvent/contacting medium. I, II, IIIa, IIIb, wherein, R1, R2, R3 and R4 are as defined in the description.