440368-70-7

Basic information

• Product Name: 2-(cyclopentyl-hydroxy-methyl)-1-(4-methoxy-phenyl)-butan-1-one
• CAS NO: 440368-70-7
• Molecular Weight: 276.376
• Mol File: 440368-70-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(cyclopentyl-hydroxy-methyl)-1-(4-methoxy-phenyl)-butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(cyclopentyl-hydroxy-methyl)-1-(4-methoxy-phenyl)-butan-1-one(440368-70-7)
• EPA Substance Registry System: 2-(cyclopentyl-hydroxy-methyl)-1-(4-methoxy-phenyl)-butan-1-one(440368-70-7)

Safety Data

• Hazardous Substances Data: 440368-70-7(Hazardous Substances Data)

Upstream product

• 872-53-7 cyclopentanealdehyde 
• 4160-51-4 1-(4-methoxyphenyl)-1-butanone 

Downstream Products

• 440368-78-5 5-cyclopentyl-4-ethyl-1,3-bis-(4-methoxy-phenyl)-1H-pyrazole 

Relevant articles and documents

Diaryl-dialkyl-substituted pyrazoles: Regioselective synthesis and binding affinity for the estrogen receptor

We have developed two novel series of tetrasubstituted pyrazoles, embodying 1,3-diaryl-4,5-dialkyl or 3,5-diaryl-1,4-dialkyl substitution patterns. The scope of a regioselective method, developed by us earlier, was expanded to allow the synthesis of the first series of these tetrasubstituted pyrazoles directly from α,β-unsaturated ketones. The binding affinity of some of these pyrazoles for the estrogen receptor (ER) subtypes ERα and ERβ is very high, and the overall affinity pattern suggests the importance of three phenol substituents for high affinity, ERα-selective binding.