41662-50-4Relevant articles and documents
Solventless synthesis of acyl phosphonamidates, precursors to masked bisphosphonates
Crossey, Kerri,Migaud, Marie E.
, p. 11088 - 11091 (2015/07/07)
A series of acyl phosphonamidates, the synthetic precursors to bisphosphonates, have been readily prepared from phosphoramidite type reagents and a range of acid chlorides. These reactions were performed using solventless conditions, where purification was easily achieved using column chromatography with yields ranging from 71-90%. Furthermore, we have demonstrated that these acyl phosphonamidates could be used for the preparation of unsymmetrical bisphosphonates, which do date are scarcely reported in the literature.
