417721-38-1

Basic information

• Product Name: 6-carbamoyl-4-(4-amino-3-fluorophenoxy)-7-methoxyquinoline
• Synonyms: 6-carbamoyl-4-(4-amino-3-fluorophenoxy)-7-methoxyquinoline
• CAS NO: 417721-38-1
• Molecular Weight: 327.315
• Mol File: 417721-38-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-carbamoyl-4-(4-amino-3-fluorophenoxy)-7-methoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-carbamoyl-4-(4-amino-3-fluorophenoxy)-7-methoxyquinoline(417721-38-1)
• EPA Substance Registry System: 6-carbamoyl-4-(4-amino-3-fluorophenoxy)-7-methoxyquinoline(417721-38-1)

Safety Data

• Hazardous Substances Data: 417721-38-1(Hazardous Substances Data)

Upstream product

• 417721-37-0 6-Carbamoyl-4-(3-fluoro-4-nitrophenoxy)-7-methoxyquinoline 
• 205448-66-4 methyl 4-chloro-7-methoxyquinoline-6-carboxylate 
• 417721-36-9 4‐chloro‐7‐methoxyquinoline‐6‐carboxamide 
• 399-95-1 4-amino-3-fluorophenol 

Downstream Products

• 417714-45-5 4-(4-((4-Fluoroanilino)carbonyl)amino-3-fluorophenoxy)-7-methoxy-6-quinolinecarboxamide 
• 417722-83-9 phenyl N-(4-(6-carbamoyl-7-methoxy-4-quinolyl) oxy-2-fluorophenyl)carbamate 

Relevant articles and documents

Multi-target tyrosine kinase inhibitor as well as preparation method and application thereof

The invention provides a compound as shown in a formula I or pharmaceutically acceptable salt thereof, which can inhibit various tyrosine kinases, has an inhibiting effect on VEGFR1, VEGFR2, VEGFR3, FGFR1, FGFR 2, FGFR 3, FGFR 4, PDGFR alpha, KIT, RET and the like, is used as a multi-target tyrosine kinase inhibitor, and has a potential application prospect in prevention and/or treatment of tumors related to tyrosine kinase overexpression.