4185-00-6 Usage
Description
7a-Hydroxy-3-oxo-5b-cholanoic acid, also known as a keto bile acid derivative, is a 3-oxo steroid that is derived from chenodeoxycholic acid. In this compound, the hydroxy group at position 3 has undergone formal oxidation to the corresponding ketone. This chemical modification gives it unique properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
7a-Hydroxy-3-oxo-5b-cholanoic acid is used as an intermediate compound for the synthesis of various pharmaceutical products. Its unique structure allows it to be a key component in the development of drugs targeting specific medical conditions.
Used in Chemical Research:
In the field of chemical research, 7a-Hydroxy-3-oxo-5b-cholanoic acid serves as a valuable compound for studying the properties and reactions of steroidal compounds. Its unique structure provides insights into the behavior of similar molecules and can contribute to the advancement of chemical knowledge.
Used in Drug Delivery Systems:
Similar to gallotannin, 7a-Hydroxy-3-oxo-5b-cholanoic acid can be employed in the development of novel drug delivery systems. Its unique properties may allow for improved targeting and delivery of therapeutic agents, potentially enhancing their efficacy and reducing side effects.
Used in Cholesterol Metabolism Studies:
As a derivative of chenodeoxycholic acid, 7a-Hydroxy-3-oxo-5b-cholanoic acid can be used in research related to cholesterol metabolism and bile acid synthesis. Understanding its role in these processes can provide valuable information for the development of treatments for conditions related to cholesterol imbalances.
Check Digit Verification of cas no
The CAS Registry Mumber 4185-00-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,8 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4185-00:
(6*4)+(5*1)+(4*8)+(3*5)+(2*0)+(1*0)=76
76 % 10 = 6
So 4185-00-6 is a valid CAS Registry Number.
4185-00-6Relevant articles and documents
Enzymatic α/β Inversion of C-3 Hydroxyl of Bile Acids and Study of the Effects of Organic Solvents on Reaction Rates
Riva, Sergio,Bovara, Roberto,Zetta, Lucia,Pasta, Piero,Ottolina, Gianluca,Carrera, Giacomo
, p. 88 - 92 (1988)
Enzymatic α/β inversion of the C-3 hydroxyl of numerous bile acids containing different numbers of hydroxyl groups in the skeleton and side chains of different lengths has been carried out.Inversion was obtained in two steps through the sequential use of the commercial enzymes 3α- and 3β-hydroxysteroid dehydrogenase, employed in the free form or immobilized on Eupergit C.The transformations were practically quantitative and the products more than 98percent pure.NAD was regenerated in situ with the pyruvate/lactic dehydrogenase system and NADH with the formate/formate dehydrogenase system.The effects of product inhibition on reaction rates and the favorable effects produced by low concentrations (7-10percent, v/v) of ethyl acetate and ethanol were also examined.
Regiospecific oxidoreductions catalyzed by a new Pseudomonas paucimobilis hydroxysteroid dehydrogenase
Bianchini, Ercolina,Chinaglia, Nicola,Dean, Mariangela,Giovannini, Pier Paolo,Medici, Alessandro,Pedrini, Paola,Poli, Silvia
, p. 1391 - 1398 (2007/10/03)
The preparative-scale regio- and stereo-specific oxidation of hydroxy groups and reduction of keto functions at C(3) of several C21 bile acids, catalyzed by a new 3α-hydroxysteroid dehydrogenase (3α-HSDH) is reported. The crude enzyme, isolated from the cells of Pseudomonas paucimobilis, revealed the presence of a further enzymatic fraction containing a secondary alcohol dehydrogenase (SADH), that has been used to recycle the cofactor.
