41926-59-4

Basic information

• Product Name: 2-(6-nitro-1H-benzimidazol-2-yl)guanidine
• Synonyms: 1-(5-nitro-1H-benzimidazol-2-yl)guanidine; guanidine, N-(5-nitro-1H-benzimidazol-2-yl)-
• CAS NO: 41926-59-4
• Molecular Formula: C₈H₈N₆O₂
• Molecular Weight: 220.1881
• Mol File: 41926-59-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 558.4°C at 760 mmHg
• Flash Point: 291.5°C
• Density: 1.87g/cm³
• Vapor Pressure: 1.68E-12mmHg at 25°C
• Refractive Index: 1.861
• CAS DataBase Reference: 2-(6-nitro-1H-benzimidazol-2-yl)guanidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-nitro-1H-benzimidazol-2-yl)guanidine(41926-59-4)
• EPA Substance Registry System: 2-(6-nitro-1H-benzimidazol-2-yl)guanidine(41926-59-4)

Safety Data

• Hazardous Substances Data: 41926-59-4(Hazardous Substances Data)

Usage

Structure

A guanidine derivative containing a benzimidazole ring with a nitro group attached at the 6-position

Usage

In the synthesis of various pharmaceuticals and organic materials

Unique properties

Biological activities of interest in medicinal chemistry research

Potential applications

Development of new materials and chemical processes

Upstream product

• 127099-85-8 N-Cyanoguanidine 
• 99-56-9 4-Nitrophenylene-1,2-diamine 

Downstream Products

• 135486-10-1 C₁₆H₁₄N₈O₄ 
• 135486-07-6 1-(methylanisaldimino)-3-<5(6)-nitro-2-benzimidazolyl>guanidine 
• 135486-08-7 C₁₆H₁₄ClN₇O₂ 
• 135486-09-8 C₁₆H₁₄BrN₇O₂ 
• 135485-89-1 C₁₆H₁₅N₇O₃ 
• 135485-90-4 C₁₅H₁₂ClN₇O₂ 
• 135486-06-5 C₁₆H₁₅N₇O₂ 
• 135485-88-0 C₁₆H₁₅N₇O₂ 
• 135485-87-9 C₁₅H₁₃N₇O₂ 

Relevant articles and documents

Photocontrol of the Hv1 Proton Channel

The voltage-gated proton channel Hv1 is expressed in various human cell types, including macrophages, epithelial cells, and sperm. Hv1 opening leads to proton efflux that alkalizes the cytosol. Here, we describe light-activated Hv1 inhibitors (photoswitches) that allow controlling its activity with high spatiotemporal precision. The photoswitches comprise a light-sensitive azobenzene moiety and 2-guanidinobenzimidazole (2GBI), a known Hv1 inhibitor. In the dark, photoGBI inhibits heterologously expressed Hv1 channels. Blue light, which isomerizes the azobenzene group from trans to cis conformation, releases inhibition. We demonstrate photocontrol of native proton currents in human macrophages and sperm using photoGBI, underlining their use as valuable optochemical tools to study the function of Hv1 channels.