422-61-7

Basic information

• Product Name: PENTAFLUOROPROPIONYL FLUORIDE
• Synonyms: pentafluoro-propanoylfluorid;Perfluoropropionyl fluoride;Propanoyl fluoride, pentafluoro-;PENTAFLUOROPROPIONYL FLUORIDE;Pentafluoropropionyl fluoride 97%;Pentafluoropropionylfluoride97%;1,2,2,3,3,3-Hexafluoro-1-propanone;2,2,3,3,3-Pentafluoropropionic acid fluoride
• CAS NO: 422-61-7
• Molecular Formula: C₃F₆O
• Molecular Weight: 166.02
• EINECS: 207-019-5
• Mol File: 422-61-7.mol
• Article Data: 39

Chemical Properties

• Boiling Point: -30°C
• Flash Point: °C
• Appearance: /
• Density: 1.537g/cm³
• Vapor Pressure: 1560mmHg at 25°C
• Refractive Index: 1.247
• CAS DataBase Reference: PENTAFLUOROPROPIONYL FLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PENTAFLUOROPROPIONYL FLUORIDE(422-61-7)
• EPA Substance Registry System: PENTAFLUOROPROPIONYL FLUORIDE(422-61-7)

Safety Data

• Hazard Codes: C,T
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3308
• HazardClass: GAS, TOXIC, CORROSIVE
• Hazardous Substances Data: 422-61-7(Hazardous Substances Data)

Usage

Description

PENTAFLUOROPROPIONYL FLUORIDE is a chemical compound with the formula C3F5O, which is characterized by its fluorinated structure. It is a colorless, volatile liquid that is highly reactive due to the presence of multiple fluorine atoms. PENTAFLUOROPROPIONYL FLUORIDE is known for its unique properties, such as high chemical stability, low reactivity with other substances, and its ability to form strong bonds with other elements.

Uses

Used in Chemical Synthesis:
PENTAFLUOROPROPIONYL FLUORIDE is used as a reagent in the synthesis of perfluoroallyl fluorosulfate (FAFS), which serves as a building block for fluoroallylic compounds. These fluoroallylic compounds have a wide range of applications in various industries, including pharmaceuticals, materials science, and agrochemicals, due to their unique properties and reactivity.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, PENTAFLUOROPROPIONYL FLUORIDE is used as a key intermediate in the synthesis of various drug molecules. Its unique fluorinated structure allows for the development of new drugs with improved pharmacokinetic and pharmacodynamic properties, such as enhanced solubility, increased metabolic stability, and better bioavailability.
Used in Materials Science:
PENTAFLUOROPROPIONYL FLUORIDE is also utilized in the development of advanced materials with specific properties, such as high thermal stability, chemical resistance, and low friction. These materials can be used in various applications, including aerospace, electronics, and automotive industries, where high-performance materials are required.
Used in Agrochemicals:
In the agrochemical industry, PENTAFLUOROPROPIONYL FLUORIDE is employed in the synthesis of novel pesticides and herbicides with enhanced efficacy and selectivity. The fluorinated structure of this compound allows for the development of new active ingredients that can target specific pests or weeds while minimizing the impact on non-target organisms and the environment.

Safety Profile

May explode on contact with fluorinated catalysts. When heated to decomposition it emits toxic fumes of Fí.

InChI:InChI=1/C3F6O/c4-1(10)2(5,6)3(7,8)9

Upstream product

• 422-87-7 1-chloro-1,2,2,3,3,3-hexafluoro-1-iodo-propane 
• 116-15-4 perfluoropropylene 
• 754-34-7 1,1,1,2,2,3,3-heptafluoro-3-iodo-propane 
• 423-41-6 perfluoropropanesulfonic acid 
• 802294-64-0 propionic acid 
• 123-62-6 propionic acid anhydride 
• 116-14-3 polytetrafluoroethylene 
• 353-50-4 Carbonyl fluoride 
• 44995-78-0 3,3'oxybispropionic acid dichloride 
• 1187-93-5 trifluoromethyl trifluorovinyl ether 
• 17636-84-9 perfluoro(dimethyl-2-methoxybutylamine) 
• 109-99-9 tetrahydrofuran 
• 106-65-0 Dimethyl succinate 
• 428-59-1 Hexafluoropropene oxide 

Downstream Products

• 2203-57-8 1-fluoroxy heptafluoropropane 
• 354-64-3 Pentafluoroethyl iodide 
• 6129-62-0 2,3,3,3-tetrafluoro-2-bromopropanoyl fluoride 
• 28627-00-1 2,3,3,3-tetrafluoro-2-chloropropanoyl fluoride 
• 378-75-6 perfluoropropionic acid methyl ester 
• 426-65-3 ethyl Pentafluoropropionate 
• 375-03-1 heptafluoropropyl methyl ether 
• 422-64-0 pentafluoropropionic acid 
• 756-13-8 perfluoro-2-methylpentan-3-one 
• 684-32-2 perfluoro-3-pentanone 
• 422-04-8 pentafluoropropionitrile 
• 354-76-7 2,2,3,3,3-pentafluoropropionamide 
• 356-45-6 bis(pentafluoropropionyl)peroxide 
• 32822-50-7 N,N-Difluorperfluorpropionsaeureamid 

Relevant articles and documents

Electrochemical fluorination of N,N-dimethylperfluoroacylamides

The electrochemical fluorination (ECF) of N,N-dimethylperfluoroacylamides gives the corresponding perfluoro-N,N-dimethylacylamides in low yield. With increase of the number of carbon atoms in the perfluoroacyl radical the yield of the required perfluoro-N

Method for preparing pentafluoride ethyl perfluoro isopropyl ketone through gas phases

The invention discloses a method for preparing pentafluoride ethyl perfluoro isopropyl ketone through gas phases. The method is characterized in that under the existence of addition catalysts, hexafluoropropylene and hexafluoropropylene oxide or pentafluoropropionyl fluoride take gas phase addition reaction to obtain the pentafluoride ethyl perfluoro isopropyl ketone, or tetrafluoroethylene and heptafluorobutyl fluoride take gas phase addition reaction to obtain the pentafluoride ethyl perfluoro isopropyl ketone. The method has the advantages that the reaction route is short; in addition, rawmaterials such as the hexafluoropropylene, the tetrafluoroethylene, the hexafluoropropylene oxide and carbonyl fluoride can be easily obtained; the cost is low; the yield of the pentafluoride ethyl perfluoro isopropyl ketone is high; the continuous large-scale industrial production can be realized through the route.

Trifluoromethyl Benzoate: A Versatile Trifluoromethoxylation Reagent

Trifluoromethyl benzoate (TFBz) is developed as a new shelf-stable trifluoromethoxylation reagent, which can be easily prepared from inexpensive starting materials using KF as the only fluorine source. The synthetic potency of TFBz is demonstrated by trifluoromethoxylation-halogenation of arynes, nucleophilic substitution of alkyl (pseudo)halides, cross-coupling with aryl stannanes, and asymmetric difunctionalization of alkenes. The unprecedented trifluoromethoxylation-halogenation of arynes proceeds smoothly at room temperature with the aid of a crown ether-complexed potassium cation, which significantly stabilizes the trifluoromethoxide anion derived from TFBz.

One stone two birds: Degradation of persistent organic pollutants to a valuable industrial chemical production of pentafluoropropionyl fluoride from HFPO oligomers catalyzed by cesium fluoride in tetraglyme

Hexafluoropropylene oxide (HFPO) oligomers are toxic, bioaccumulative, and persistent organic pollutants (POPs). Consuming the harmful chemicals to prevent them from releasing to nature is of serious significance as far as both natural environments and human health are concerned. In this study, investigation on degradation of HFPO oligomers to pentafluoropropionyl fluoride (PPF), a valuable industrial chemical, is reported. Different combinations of alkali metal fluoride in either diglyme or tetraglyme under both flask and batch autoclave conditions were examined. Under the optimal reaction conditions, HFPO oligomers (n?=?2–10) were completely degraded to PPF in over 90% yield. Reactions on 200?g scale were tested and no deduction of efficiency was observed, which indicates the potential for practical industrial application of this chemistry.