42205-75-4

Basic information

• Product Name: (2R,4R)-ethyl 4-Methylpiperidine-2-carboxylate
• Synonyms: (2R,4S)-ethyl 4-methylpiperidine-2-carboxylate(WX900194)
• CAS NO: 42205-75-4
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.23678
• Mol File: 42205-75-4.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 226.1±33.0 °C(Predicted)
• Appearance: /
• Density: 0.969±0.06 g/cm3(Predicted)
• PKA: 6.65±0.10(Predicted)
• CAS DataBase Reference: (2R,4R)-ethyl 4-Methylpiperidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-ethyl 4-Methylpiperidine-2-carboxylate(42205-75-4)
• EPA Substance Registry System: (2R,4R)-ethyl 4-Methylpiperidine-2-carboxylate(42205-75-4)

Safety Data

• Hazardous Substances Data: 42205-75-4(Hazardous Substances Data)

Upstream product

• 4021-08-3 4-methylpicolinic acid 
• 71-41-0 pentan-1-ol 
• 123387-50-8 4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 162167-52-4 (2R-trans)-1-[(Phenylmethoxy)carbonyl]-4-methyl-2-piperidinecarboxylic acid, ethyl ester 
• 64-17-5 ethanol 
• 134984-62-6 ethyl cis-(2S,4R)-1-<(R)-1-phenylethyl>-4-methylpipecolate 
• 134984-61-5 (6S)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-4-methyl-3,4-didehydropiperidine 
• 78-79-5 isoprene 
• 66937-93-7 4(R)-Methylpiperidine-2(R)-carboxylic acid ethyl ester 
• 134984-62-6 (2R,4R)-4-Methyl-1-((R)-1-phenyl-ethyl)-piperidine-2-carboxylic acid ethyl ester 
• 139334-62-6 (6R)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-4-methyl-3,4-didehydropiperidine 
• 139334-63-7 ethyl (2R)-4-methyl-1-((S)-1-phenylethyl)-1,2,3,6-tetrahydropyridine-2-carboxylate 
• 198641-56-4 ethyl (2R,4R)-4-methyl-1-((S)-1-phenylethyl)tetrahydropyridine-2-carboxylate 
• 626-58-4 4-methylpiperidin 

Downstream Products

• 74863-81-3 ethyl 1-α-(tert-butoxycarbonyl)-N^ω-nitro-L-arginyl>-4-methyl-2-piperidinecarboxylate 
• 4939-37-1 2-methylquinolizidine 
• 131278-84-7 ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate L-(+)-tartarate 
• 1401618-23-2 ethyl (2S,4S)-4-methyl-2-piperidinecarboxylate L-tartrate 
• 74874-07-0 ethyl (2R,4R)-1-[(2S)-2-[[(1,1-dimethyletoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate 
• 1401618-20-9 ethyl (2S,4S)-1-[(2S)-2-[[(1,1-dimethyletoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate 
• 1401618-20-9 ethyl (2S,4S)-1-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate 
• 74874-07-0 ethyl (2R,4R)-1-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate 
• 74892-82-3 ethyl (2R-trans)-4-methylpiperidine-2-carboxylate 
• 79199-62-5 ethyl (2S,4R)-4-methylpipecolate 

Relevant articles and documents

Method for splitting argatroban isomer impurity

The invention provides a method for splitting an argatroban isomer impurity. The method comprises the following steps: performing salt formation by taking 4-methyl-2-piperidinecarboxylate racemate asa raw material and taking D-tartaric acid as a splitting agent to obtain (2S,4S)-4-methyl-2-piperidinecarboxylate-D-tartrate shown by a compound I; dissociating the compound I under an alkaline condition to obtain (2S,4S)-4-methyl-2-piperidinecarboxylate shown by a compound II. The splitting method provided by the invention is easy and convenient to operate, the total yield of splitting reaches 46.5 percent, and the chiral purity after splitting can reach 99.2 percent.

Method for splitting isomer impurity of agathiban starting material

The invention provides a method for splitting the isomer impurity of an argatroban starting material. The method comprises the following steps: performing salt formation by taking 4-methyl-2-piperidinecarboxylate racemate as a raw material and taking D-(+

Preparation method of argatroban intermediate esterified substance 4-methyl-2-ethyl piperidinecarboxylate

The invention relates to a preparation method of an argatroban intermediate esterified substance 4-methyl-2-ethyl piperidinecarboxylate. The preparation method comprises the following steps: adding a solvent, namely ethanol into a reaction kettle, putting a reactant, namely 4-methyl-2-piperidinecarboxylicacid hydrochloride into the reaction kettle, stirring to cool to (-5)-0 DEG C, maintaining the temperature, adding a catalyst, namely thionyl chloride, stirring to completely react until disappearance of raw material points is detected by virtue of a thin-layer chromatography, and carrying out vacuum reduced pressure concentration at 60 DEG C, so as to remove the solvent; and cooling the room temperature, adding dichloromethane, neutralizing reaction liquid by virtue of a 10% Na2CO3 solution, carrying out layered extraction, drying an organic solvent, and carrying out vacuum reduced pressure concentration at 50 DEG C on the organic solvent to remove the solvent, so as to obtain the esterified substance 4-methyl-2-ethyl piperidinecarboxylate. Mixed solvents including glacial acetic acid, ethanol and chloroform are replaced with single ethanol in a synthetic process, the reaction pressure is reduced, the catalyst thionyl chloride is low in cost, the operation is simple and convenient, the yield is substantially increased, and reaction solvents can be recycled, so that the preparation method is relatively beneficial to large-scale industrial production.