423184-29-6

Basic information

• Product Name: 1-bromo-3-(4-fluorophenyl)propan-2-one
• Synonyms: 1-bromo-3-(4-fluorophenyl)propan-2-one
• CAS NO: 423184-29-6
• Molecular Formula: C₉H₈BrFO
• Molecular Weight: 231.0616232
• Mol File: 423184-29-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-bromo-3-(4-fluorophenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-3-(4-fluorophenyl)propan-2-one(423184-29-6)
• EPA Substance Registry System: 1-bromo-3-(4-fluorophenyl)propan-2-one(423184-29-6)

Safety Data

• Hazardous Substances Data: 423184-29-6(Hazardous Substances Data)

Usage

Organic compound

1-bromo-3-(4-fluorophenyl)propan-2-one is an organic compound, meaning it is primarily composed of carbon, hydrogen, and other elements such as bromine and fluorine.

Synthetic chemical

This compound is synthetic, meaning it is man-made and not naturally occurring.

Bromine and fluorine atoms

The compound contains a bromine and fluorine atom attached to a phenyl ring, which contributes to its chemical properties and reactivity.

Ketone functional group

The presence of a ketone functional group (C=O) in the compound gives it specific chemical properties and reactivity.

Use as an intermediate

1-bromo-3-(4-fluorophenyl)propan-2-one is primarily used as an intermediate in the synthesis of pharmaceuticals and other organic compounds, meaning it is a key component in creating other chemicals.

Research and development

The compound is also used in research and development for its potential biological activity, indicating that it may have applications in the field of medicine or other biological sciences.

Flammability and hazardous nature

This chemical is flammable and potentially hazardous, requiring careful handling and storage.

Professional use only

1-bromo-3-(4-fluorophenyl)propan-2-one should only be used by trained professionals in a controlled laboratory setting to minimize the risk of accidents or exposure to harmful substances.

Upstream product

• 459-03-0 4-fluorophenyl acetone 
• 684-93-5 1-methyl-1-nitrosourea 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 405-50-5 p-Fluorophenylacetic acid 
• 423184-24-1 1-diazo-3-(4-fluoro-phenyl)-propan-2-one 

Downstream Products

• 123437-16-1 2-(4-fluorophenylmethyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one 
• 500367-36-2 4-(4-fluorobenzyl)-2-isopropenyloxazole 
• 1232038-67-3 8-bromo-2-(4-fluorobenzyl)imidazo[1,2-a]pyridine 
• 1232395-00-4 [2-(4-fluorobenzyl)imidazo[1,2-a]pyridin-8-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine 

Relevant articles and documents

SUBSTITUTED BICYCLIC IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted bicyclic imidazole derivatives of Formula (I) wherein R0, R1, R3, R4, X, A1, A2, A3, A4, Y1, Y2 and Y3 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said novel compound as an active ingredient as well as the use of said compounds as a medicament.

THERAPEUTIC AGENT FOR CANCER

A medicament for the prevention and/or treatment of cancers and the like which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is 1? a fused polycyclic heteroaryl group wherein the ring which binds directly to ―CONH― group in the formula (I) is a benzene ring, 2? unsubstituted thiazol-2-yl group, or 3? unsubstituted benzothiazol-2-yl group is excluded, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula ―CONH―E wherein E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula ― CONH―E wherein E has the same meaning as that defined above.

ANTIVIRAL AGENT

The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, R C and R D taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxy, mercapto or amino; Z is O, S or NH ; R A is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like)