42409-58-5

Basic information

• Product Name: 5-BROMO-3-METHOXYPYRIDIN-2-AMINE
• Synonyms: 5-BROMO-3-METHOXYPYRIDIN-2-AMINE;2-AMINO-5-BROMO-3-METHOXYPYRIDINE;2-Amino-3-methoxy-5-bromopyridine;2-PyridinaMine,5-broMo-3-Methoxy-;5-BroMo-3-Methoxy-pyridin-2-ylaMine
• CAS NO: 42409-58-5
• Molecular Formula: C6H7BrN2O
• Molecular Weight: 203.04
• Mol File: 42409-58-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 78-82℃
• Boiling Point: 254℃
• Flash Point: 107℃
• Appearance: /
• Density: 1.622
• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.93±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-3-METHOXYPYRIDIN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-METHOXYPYRIDIN-2-AMINE(42409-58-5)
• EPA Substance Registry System: 5-BROMO-3-METHOXYPYRIDIN-2-AMINE(42409-58-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 42409-58-5(Hazardous Substances Data)

Usage

General Description

The chemical 5-Bromo-3-methoxypyridin-2-amine is a compound with the molecular formula C6H7BrN2O, and a molar mass of 200.04 g/mol. It is a pyridine derivative with a bromine atom and a methoxy group attached to the 3rd and 2nd carbon atoms, respectively. 5-Bromo-3-methoxypyridin-2-amine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its chemical properties make it a useful building block for the production of various drugs and pesticides. Additionally, it has potential applications in research and development of new chemical compounds due to its unique structure and reactivity.

InChI:InChI=1/C6H7BrN2O/c1-10-5-2-4(7)3-9-6(5)8/h2-3H,1H3,(H2,8,9)

Upstream product

• 50720-12-2 3-bromo-5-methoxypyridine 
• 625-92-3 3,5-dibromopyridine 
• 54231-35-5 3-fuoro-2-nitropyridine 
• 78156-39-5 3-bromo-5-methoxypyridine 1-oxide 
• 20265-37-6 3-methoxy-2-nitropyridine 
• 152684-26-9 5-bromo-3-methoxy-2-nitropyridine 
• 10201-71-5 3-methoxypyridin-2-amine 
• 856850-22-1 5-bromo-3-methoxy-2-nitro-pyridine-1-oxide 

Downstream Products

• 52605-98-8 5-bromo-2,3-dimethoxypyridine 
• 1171919-88-2 2,3-dimethoxy-5-[(trimethylsilyl)ethynyl]pyridine 
• 2171029-30-2 6-bromo-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine 
• 1516750-51-8 ethyl 6-bromo-8-methoxyimidazo[1,2-a]pyridine-2-carboxylate 
• 1188301-91-8 5-(5-bromo-2-(4-fluorophenyl)thiazol-4-yl)-3-methoxypyridin-2-amine 
• 1188301-90-7 5-(2-(4-fluorophenyl)thiazol-4-yl)-3-methoxypyridin-2-amine 
• 1450019-01-8 2-(4-(4-(6-amino-5-methoxypyridin-3-yl)-2-phenyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol trifluroacetate 
• 1450018-76-4 3-methoxy-5-(5-(pyridine-4-yl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyridin-2-amine trifluoroacetate 
• 1188301-65-6 5-(5-bromo-2-(4-trifluoromethyl)phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxypyridin-2-amine 
• 1450018-72-0 3-methoxy-5-(2-phenyl-5-(pyridine-4-yl)-1H-imidazol-4-yl)pyridine-2-amine 
• 1188301-89-4 5-bromo-2-phenyl-4-(pyridin-4-yl)thiazole 
• 1450020-21-9 3-methoxy-5-(2-phenyl-4-(pyridine-4-yl)thiazol-5-yl)pyridine-2-amine trifluoroacetate 
• 1188298-68-1 5-(2-(4-fluorophenyl)-5-(pyridin-4-yl)oxazol-4-yl)-3-methoxypyridin-2-amine 
• 1188301-84-9 5-(5-bromo-2-(4-fluorophenyl)oxazol-4-yl)-3-methoxypyridin-2-amine 

Relevant articles and documents

Directing Group Enables Electrochemical Selectively Meta-Bromination of Pyridines under Mild Conditions

Without the use of catalysts and oxidants, a facile and sustainable electrochemical bromination protocol was developed. By introducing the directing groups, the regioselectivity of pyridine derivatives could be controlled at themeta-position utilizing the inexpensive and safe bromine salts at room temperature. A variety of brominated pyridine derivatives were obtained in 28-95% yields, and the reaction could be readily performed at a gram scale. By combining the installation and removing the directing group, the concept ofmeta-bromination of pyridines could be verified.

NOVEL COMPOUNDS FOR MODULATION OF ROR-GAMMA ACTIVITY

The present invention relates to aryl sulfones and related compounds that are modulators of ROR-gamma receptors. The invention also provides pharmaceutical compositions comprising these modulators, and methods of modulating ROR-gamma receptors using them. Also provided are methods of using aryl sulfones and related compounds as modulators of ROR-gamma to treat ROR-gamma mediated diseases

An efficient, regioselective amination of 3,5-disubstituted pyridine N-oxides using saccharin as an ammonium surrogate

A process for the regioselective amination of unsymmetrical 3,5-substituted pyridine N-oxides has been developed utilizing cheap, readily available saccharin as an ammonium surrogate. High conversions of the corresponding saccharin adducts have been achieved under mild reaction conditions. In situ deprotection under acidic conditions allows for a one-pot process to substituted aminopyridines. High regioselectivities were obtained from a variety of 3,5-disubstituted pyridine N-oxides.