42457-13-6

Basic information

• Product Name: 2-cyano-2-methylpyrrolidine
• Synonyms: 2-cyano-2-methylpyrrolidine
• CAS NO: 42457-13-6
• Molecular Weight: 110.159
• Mol File: 42457-13-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-cyano-2-methylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-2-methylpyrrolidine(42457-13-6)
• EPA Substance Registry System: 2-cyano-2-methylpyrrolidine(42457-13-6)

Safety Data

• Hazardous Substances Data: 42457-13-6(Hazardous Substances Data)

Upstream product

• 5891-21-4 5-chloro-2-pentanone 
• 773837-37-9 sodium cyanide 

Downstream Products

• 132235-43-9 (S)-2-methylpyrrolidine-2-carboxylic acid amide 
• 132235-42-8 (2R)-2-methyl-2-pyrrolidinecarboxamide 
• 42856-71-3 (S)-2-methylpyrrolidine-2-carboxylic acid 

Relevant articles and documents

METHOD FOR PRODUCING OPTICALLY ACTIVE ALPHA-SUBSTITUTED PROLINE

The present invention aims to provide an industrial method practically suitable for producing optically active α-substituted prolines from an acyclic ketone compound by a small number of steps under mild conditions. The present invention relates to a production method of an optically active α-substituted proline (4) and/or an optically active α-substituted prolinamide (5), including (a) reacting an acyclic ketone compound (1) with at least one selected from ammonia, an ammonium salt, primary amine and a salt of primary amine, and a cyanating agent to give a cyclic nitrogen-containing compound (2), (b) hydrating the cyclic nitrogen-containing compound (2) to give an α-substituted prolinamide (3), and (c) resolving the α-substituted prolinamide (3) by one or more of (d) enzymatical hydrolysis, (e) resolution by diastereomeric salt formation, and (f) separation by column chromatography.