132235-42-8Relevant articles and documents
Α-substd. provitamin optically active production of phosphorus
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, (2016/12/26)
PROBLEM TO BE SOLVED: To provide an industrial method practically suitable for producing an optically active α-substituted prolines with short process and mild conditions.SOLUTION: A method of producing an optically active α-substituted prolines (6) includes (d) a step of obtaining an optically active N, α-substituted prolines (5) by hydrolysis of an optically active N, α-substituted proline amides (4), and (e) a step of obtaining an optically active α-substituted prolines (6) by eliminating the optically active N, and a protective group Rof the α-substituted prolines (5).
Is the backbone conformation of Cα-methyl proline restricted to a single region?
De Poli, Matteo,Moretto, Alessandro,Crisma, Marco,Peggion, Cristina,Formaggio, Fernando,Kaptein, Bernard,Broxterman, Quirinus B.,Toniolo, Claudio
experimental part, p. 8015 - 8025 (2010/03/31)
Cα-Methyl-L-proline, or L(αMe)Pro, is probably the most conformational constrained α-amino acid. In particular, its ω and o torsion angles are restricted to about 180 and -60°, respectively, and only three ranges of values are theoretically ava
