42523-29-5

Basic information

• Product Name: 2,7-Dihydroxy-9-fluorenone
• Synonyms: 2,7-DIHYDROXY-9-FLUORENONE;2,7-DIHYDROXYFLUORENONE;http://www.linchuanchem.com/product-e41.htm;2,7-DIHYDROXY-9-FLUORENONE 98%;2,7-Dihydroxy-9H-fluoren-9-one;2,7-Dihydroxy-fluoren-9-one;2,7-Dihydroxy-9-fluo;7-Dihydroxy-9-fluorenone
• CAS NO: 42523-29-5
• Molecular Formula: C₁₃H₈O₃
• Molecular Weight: 212.2
• Product Categories: Fluorene Derivatives;Fluorenes, Flurenones;Fluorene series
• Mol File: 42523-29-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 338 °C
• Boiling Point: 444.5 °C at 760 mmHg
• Flash Point: 236.7 °C
• Appearance: Brown red powder
• Density: 1.497 g/cm³
• Vapor Pressure: 1.63E-08mmHg at 25°C
• Refractive Index: 1.749
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.87±0.20(Predicted)
• CAS DataBase Reference: 2,7-Dihydroxy-9-fluorenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,7-Dihydroxy-9-fluorenone(42523-29-5)
• EPA Substance Registry System: 2,7-Dihydroxy-9-fluorenone(42523-29-5)

Safety Data

• Hazardous Substances Data: 42523-29-5(Hazardous Substances Data)

Usage

Chemical Properties

Dark red crystal or powder

Uses

2,7-dihydroxy-9-fluorenone is used as organic intermediates.

InChI:InChI=1/C13H8O3/c14-7-1-3-9-10-4-2-8(15)6-12(10)13(16)11(9)5-7/h1-6,14-15H

Synthetic route

9-oxo-9H-fluorene-2,7-diyl diacetate (53133-99-6) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
With potassium hydroxide for 2h; Heating;	97.6%

4,4'-dihydroxy-biphenyl-2-carboxylic acid methyl ester (765944-63-6) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
With zinc(II) chloride at 110 - 120℃; for 2h;	95%
Multi-step reaction with 2 steps 1: sodium hydroxide / ethanol / 78 °C 2: thionyl chloride / 79 °C View Scheme

4,4'-dihydroxy-[1,1'-biphenyl]-2-carboxylic acid (53197-57-2) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
With zinc(II) chloride at 210℃; Neat (no solvent);	90%
With zinc(II) chloride
With zinc(II) chloride at 200℃;
With thionyl chloride at 79℃; Friedel-Crafts acylation;
Multi-step reaction with 2 steps 1: sulfuric acid / methanol / 2 h / Reflux 2: zinc(II) chloride / 2 h / 110 - 120 °C View Scheme

2,7-dimethoxy-9H-fluorenon-9-one (42523-28-4) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
With hydrogen bromide; acetic acid In water for 12h; Reflux;	87%
With hydrogen bromide In acetic acid

4-bromo-3-iodo-phenol (202865-84-7) + meta-hydroxybenzaldehyde (100-83-4) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
With palladium diacetate; potassium hydrogencarbonate; DL-Pro-NHMe In tert-Amyl alcohol at 120℃; for 24h; Inert atmosphere;	74%

2,7-dihydroxy-9-oxo-fluorene-1-carboxylic acid (89450-82-8) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
With calcium oxide melting;

Fluorenon-Tetrazonium Tetrafluoroborat → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
With sulfuric acid

diazotized 2.7-diamino-fluorenone → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

(p-hydroxyphenyl)boronic acid (71597-85-8) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium carbonate / tris(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxy-ethane; H2O / 85 °C 2: sodium hydroxide / ethanol / 78 °C 3: thionyl chloride / 79 °C View Scheme

methyl 2-bromo-5-hydroxybenzoate (154607-00-8) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium carbonate / tris(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxy-ethane; H2O / 85 °C 2: sodium hydroxide / ethanol / 78 °C 3: thionyl chloride / 79 °C View Scheme

3-(p-anisyl)-6-hydroxyphthalic anhydride (84185-72-8) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: 87 percent / AlCl3 / benzene / Heating 2: CaO / melting View Scheme

4-Hydroxy-4'-methoxy-biphenyl-2,3-dicarboxylic acid (84185-84-2) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: 66 percent 2: 87 percent / AlCl3 / benzene / Heating 3: CaO / melting View Scheme

2,7-dinitro-9-fluorenone (31551-45-8) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) SnCl2, HCl, AcOH, (ii) NaOH 2: aq. HBF4, NaNO2 3: aq. H2SO4 View Scheme

2,7-diaminofluoren-9-one (2915-84-6) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. HBF4, NaNO2 2: aq. H2SO4 View Scheme

para-iodoanisole (696-62-8) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) Cu, (ii) aq. NaOH, MeOH 2: polyphosphoric acid 3: aq. HBr / acetic acid View Scheme
Multi-step reaction with 2 steps 1: silver trifluoroacetate; acetic acid; 1,1,1,3',3',3'-hexafluoro-propanol / 36 h / 120 °C / Sealed tube 2: acetic acid; hydrogen bromide / water / 12 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: anthranilic acid; palladium diacetate; silver trifluoroacetate; acetic acid; 1,1,1,3',3',3'-hexafluoro-propanol / 36 h / 120 °C / Sealed tube 2: acetic acid; hydrogen bromide / water / 12 h / Reflux View Scheme

methyl 2-bromo-5-methoxybenzoate (35450-36-3) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) Cu, (ii) aq. NaOH, MeOH 2: polyphosphoric acid 3: aq. HBr / acetic acid View Scheme

4,4'-dimethoxy-[1,1'-biphenyl]-2-carboxylic acid (42523-25-1) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: polyphosphoric acid 2: aq. HBr / acetic acid View Scheme

9H-fluorene (86-73-7) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Stage #1: 9H-fluorene With aluminum (III) chloride; acetic anhydride Stage #2: With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid In chloroform Further stages;
Multi-step reaction with 4 steps 1.1: sulfuric acid / 100 °C 1.2: 100 °C 2.1: potassium permanganate / water / Heating 3.1: sodium hydroxide 4.1: zinc(II) chloride / 210 °C / Neat (no solvent) View Scheme
Multi-step reaction with 5 steps 1.1: sulfuric acid / water / 2 h / 110 - 115 °C 1.2: 0.5 h / 20 °C 2.1: potassium permanganate / water / 2 h / 20 - 30 °C 3.1: potassium hydroxide; sodium hydroxide / 1 h / 270 - 300 °C 4.1: sulfuric acid / methanol / 2 h / Reflux 5.1: zinc(II) chloride / 2 h / 110 - 120 °C View Scheme

9H-fluorene-2,7-disulfonic acid dipotassium salt (13354-15-9) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium permanganate / water / Heating 2: sodium hydroxide 3: zinc(II) chloride / 210 °C / Neat (no solvent) View Scheme
Multi-step reaction with 4 steps 1: potassium permanganate / water / 2 h / 20 - 30 °C 2: potassium hydroxide; sodium hydroxide / 1 h / 270 - 300 °C 3: sulfuric acid / methanol / 2 h / Reflux 4: zinc(II) chloride / 2 h / 110 - 120 °C View Scheme

9-oxo-9H-fluorene-2,7-disulfonic acid dipotassium salt → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium hydroxide; sodium hydroxide / 1 h / 270 - 300 °C 2: sulfuric acid / methanol / 2 h / Reflux 3: zinc(II) chloride / 2 h / 110 - 120 °C View Scheme

3-methoxy-benzaldehyde (591-31-1) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: anthranilic acid; palladium diacetate; silver trifluoroacetate; acetic acid; 1,1,1,3',3',3'-hexafluoro-propanol / 36 h / 120 °C / Sealed tube 2: acetic acid; hydrogen bromide / water / 12 h / Reflux View Scheme
Multi-step reaction with 3 steps 1: 1,1,1,3',3',3'-hexafluoro-propanol / 8 h / 110 °C / Inert atmosphere 2: silver trifluoroacetate; acetic acid; 1,1,1,3',3',3'-hexafluoro-propanol / 36 h / 120 °C / Sealed tube 3: acetic acid; hydrogen bromide / water / 12 h / Reflux View Scheme

C20H16N2O3Pd → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: silver trifluoroacetate; acetic acid; 1,1,1,3',3',3'-hexafluoro-propanol / 36 h / 120 °C / Sealed tube 2: acetic acid; hydrogen bromide / water / 12 h / Reflux View Scheme

2,7-dibromofluorene-9-one (14348-75-5) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Conditions	Yield
With lithium hydroxide monohydrate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; copper(II) acetylacetonate In water; dimethyl sulfoxide at 120℃; for 4h;	865 mg

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + benzyl bromide (100-39-0) → 2,7-bis-benzoyloxy-fluoren-9-one

Conditions	Yield
With potassium carbonate In acetone for 12h; Reflux;	96%

1-bromo-octane (111-83-1) + 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) → 2,7-dioctyloxyfluoren-9-one

Conditions	Yield
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 1.5h; Stage #2: 1-bromo-octane In N,N-dimethyl-formamide at 120℃; for 24h;	95%
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 1h; Stage #2: 1-bromo-octane In N,N-dimethyl-formamide at 110℃; for 24h;	3.92 g

[1,3]-dioxolan-2-one (96-49-1) + 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) → 2,7-bis(2-hydroxyethoxy)-9H-fluoren-9-one (129375-33-3)

Conditions	Yield
With potassium carbonate at 100 - 120℃;	93%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + aniline (62-53-3) → 9,9-bis(4-aminophenyl)-2,7-dihydroxyfluorenone (657862-72-1)

Conditions	Yield
With trifluorormethanesulfonic acid at 150℃; for 10h; Inert atmosphere;	92.3%
With methanesulfonic acid at 150℃; for 10h;	86%
With aniline hydrochloride at 180℃; for 1h;	73.6%
With methanesulfonic acid at 150℃; for 10h;
With methanesulfonic acid at 150℃; for 14h;

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + 4-Fluoronitrobenzene (350-46-9) → 2,7-bis(4-nitrophenoxy)-9-fluorenone (1332524-31-8)

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 90℃; for 3h; Inert atmosphere;	92.2%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 90℃; for 3h; Inert atmosphere;	92.2%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) → 3,6-Dichloro-2,7-dihydroxyfluoren-9-one (84487-73-0)

Conditions	Yield
With sulfuryl dichloride In acetic acid at 42 - 45℃; regioselective reaction;	90%
With sulfuryl dichloride; acetic acid at 42 - 45℃; for 0.666667h; Inert atmosphere;	90.2%
With sulfuryl dichloride In acetic acid at 45℃; for 0.5h;	82%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + ethyl iodide (75-03-6) → 2,7-diethoxy-fluoren-9-one (303735-64-0)

Conditions	Yield
With potassium carbonate In acetone Heating;	90%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + methyl iodide (74-88-4) → 2,7-dimethoxy-9H-fluorenon-9-one (42523-28-4)

Conditions	Yield
With potassium carbonate In acetone for 4h; Heating;	90%
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 6h;	80%
With sodium hydroxide In dimethyl sulfoxide for 3h;	65%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + 1,2-dichloro-ethane (107-06-2) → 2,7-bis(2-chloroethoxy)fluoren-9-one (28686-75-1)

Conditions	Yield
With tetrabutyl-ammonium chloride; sodium hydroxide In water at 75℃; for 24h;	87%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + phenol (108-95-2) → 2,7-dihydroxy-9,9-bis(4-hydroxyphenyl)fluorene

Conditions	Yield
With 3-mercaptopropionic acid at 90 - 120℃; Green chemistry;	85.6%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + 2-chloro-N,N-diethylethylamine hydrochloride (869-24-9) → 2,7-bis(2-[diethylamino]ethoxy)-9-fluorenone (27591-97-5)

Conditions	Yield
With potassium hydroxide In water; toluene for 8h; Reflux;	85%
With potassium hydroxide In water; toluene for 24h; Reflux;	72%
With potassium hydroxide In toluene
With potassium hydroxide; trimethylbenzylammonium bromide In toluene
With potassium hydroxide In water; toluene for 24h; Reflux;

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + 1-iodo-propane (107-08-4) → 2,7-dipropoxyfluoren-9-one

Conditions	Yield
With potassium carbonate In acetone Heating;	85%

1-bromo-butane (109-65-9) + 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) → 2,7-dibutoxyl-9H-fluoren-9-one

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 20h; Inert atmosphere;	84%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + bromoacetic acid methyl ester (96-32-2) → 2,7-bis(methoxycarbonylmethoxy)fluoren-9-one (123305-05-5)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 0.5h; Heating;	83%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + 1,3-chlorobromopropane (109-70-6) → 2,7-bis(3-chloropropoxy)fluoren-9-one

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;	83%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + ethane-1,2-dithiol (540-63-6) → 2,7-dihydroxyfluoren-9-(1,3-dithiolane) (129395-16-0)

Conditions	Yield
With aluminium trichloride In 1,4-dioxane at 50℃; for 2.5h;	82%

n-butyl bromoacetate (18991-98-5) + 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) → (7-Butoxycarbonylmethoxy-9-oxo-9H-fluoren-2-yloxy)-acetic acid butyl ester (123278-11-5)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 0.5h; Heating;	80%

2-(2-(2-(2-chloroethoxy)ethoxy)ethoxy)ethanol (5197-66-0) + 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) → 2,7-bis(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)-9H-fluoren-9-one (844638-09-1)

Conditions	Yield
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 1h; Stage #2: 2-(2-(2-(2-chloroethoxy)ethoxy)ethoxy)ethanol In N,N-dimethyl-formamide at 80℃; for 35h;	80%
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 1h; Stage #2: 2-(2-(2-(2-chloroethoxy)ethoxy)ethoxy)ethanol In N,N-dimethyl-formamide at 80℃; for 35h;	80%
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 35h;	80%

14-chloro-3,6,9,12-tetraoxatetradecanol (5197-67-1) + 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) → 2,7-bis(15-hydroxy-1,4,7,10,13-pentaoxapentadecyl)-9H-fluoren-9-one (1062593-11-6)

Conditions	Yield
With potassium hydroxide; sodium iodide In ethanol for 50h; Heating;	80%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + phenylhydrazine (100-63-0) → 2,7-Dihydroxy-9-fluorenone phenylhydrazone (84487-74-1)

Conditions	Yield
In ethanol for 4h;	79%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + (2,4-dinitro-phenyl)-hydrazine (119-26-6) → 9-[(2,4-dinitro-phenyl)-hydrazono]-9H-fluorene-2,7-diol

Conditions	Yield
With sulfuric acid In methanol at 50℃; for 0.5h;	78%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + 2-(2-Chloroethoxy)ethanol (628-89-7) → 2,7-bis[2-(2-hydroxyethoxy)ethoxy]-9H-fluoren-9-one (299167-98-9)

Conditions	Yield
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 1h; Stage #2: 2-(2-Chloroethoxy)ethanol In N,N-dimethyl-formamide at 80℃; for 35h;	78%
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 1h; Stage #2: 2-(2-Chloroethoxy)ethanol In N,N-dimethyl-formamide at 80℃; for 35h;	78%
With potassium carbonate In N,N-dimethyl-formamide at 80 - 85℃; for 30h;	78%
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 35h;	78%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) + 2-chloro-ethanol (107-07-3) → 2,7-bis(2-hydroxyethoxy)-9H-fluoren-9-one (129375-33-3)

Conditions	Yield
With sodium hydroxide In water at 30 - 70℃; for 4h;	78%
With sodium hydroxide In dimethyl sulfoxide at 70℃;	55%

1,5-dibromo-pentane (111-24-0) + 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) → 2,7-bis(5-bromopentoxy)fluoren-9-one

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;	78%

2-ethylhexyl bromide (18908-66-2) + 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) → C29H40O

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 12h;	78%

2,7-dihydroxy-9H-fluoren-9-one (42523-29-5) → 3,6-Dibromo-2,7-dihydroxyfluoren-9-one (84487-72-9)

Conditions	Yield
With 1,4-dioxane dibromide at 60 - 65℃; for 0.666667h;	77%

Upstream product

• 53197-57-2 4,4'-dihydroxy-[1,1'-biphenyl]-2-carboxylic acid 
• 53133-99-6 9-oxo-9H-fluorene-2,7-diyl diacetate 
• 86-73-7 9H-fluorene 
• 13354-15-9 9H-fluorene-2,7-disulfonic acid dipotassium salt 
• 14348-75-5 2,7-dibromofluorene-9-one 
• 202865-84-7 4-bromo-3-iodo-phenol 
• 100-83-4 meta-hydroxybenzaldehyde 
• 591-31-1 3-methoxy-benzaldehyde 
• 42523-25-1 4,4'-dimethoxy-[1,1'-biphenyl]-2-carboxylic acid 
• 35450-36-3 methyl 2-bromo-5-methoxybenzoate 
• 696-62-8 para-iodoanisole 
• 2915-84-6 2,7-diaminofluoren-9-one 
• 31551-45-8 2,7-dinitro-9-fluorenone 
• 84185-84-2 4-Hydroxy-4'-methoxy-biphenyl-2,3-dicarboxylic acid 

Downstream Products

• 5043-54-9 2,7-dihydroxyfluorene 
• 84487-74-1 2,7-Dihydroxy-9-fluorenone phenylhydrazone 
• 27591-97-5 2,7-bis(2-[diethylamino]ethoxy)-9-fluorenone 
• 53197-73-2 2,7-Bis-(2-dibenzylamino-ethoxy)-fluoren-9-one 
• 657862-72-1 9,9-bis(4-aminophenyl)-2,7-dihydroxyfluorenone 
• 844638-10-4 2-{2-{2-{2-{{7-{2-{2-{2-{2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy}ethoxy}ethoxy}ethoxy}-9-oxo-9H-fluoren-2-yl}oxy}ethoxy}ethoxy}ethoxy}ethyl 4-methylbenzenesulfonate 
• 619335-39-6 2-{2-{2-{{7-{2-{2-{2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy}ethoxy}ethoxy}-9-oxo-9H-fluoren-2-yl}oxy}ethoxy}ethoxy}ethyl 4-methylbenzenesulfonate 
• 690663-71-9 2-{2-{{7-{2-{2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy}ethoxy}-9-oxo-9H-fluoren-2-yl}oxy}ethoxy}ethyl 4-methylbenzenesulfonate 
• 84487-77-4 2,7-Diadamantanoyloxy-9-fluorenone phenylhydrazone 
• 1332524-31-8 2,7-bis(4-nitrophenoxy)-9-fluorenone 
• 1332524-34-1 2,7-bis(4-aminophenoxy)fluorene 
• 1332524-33-0 2,7-bis(4-nitrophenoxy)-9-acetoxyfluorene 
• 1332524-32-9 2,7-bis(4-nitrophenoxy)-9-hydroxyfluorene 
• 1401217-94-4 2,7-bis(4-aminophenoxy)fluorene-3,6-disulfonic acid 

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PROBLEM TO BE SOLVED: To provide a novel manufacturing method of hydroxyfluorenones. SOLUTION: By the method, a compound represented by the following formula (2) is manufactured by reacting a compound (A) represented by the following formula (1) and at least one kind of metal hydroxide (B) selected from alkali metal hydroxides, alkali earth metal hydroxides, and a hydrates thereof in presence of at least one kind of Periodic Table 11 group element-containing material (C) selected from simple substance of Periodic Table 11 group elements and compound containing the element, and a compound (D) having N,N'-substituted oxamide skeleton. Ar1 and Ar2 represent each independently an arylene ring, X represent each independently a halogen atom, R1 each independently represents a substituent, m1 and m2 represent integers of 0 or more, n1 and n2 represent integers of 0 or more and n1+n2 is 1 or more. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Synthesis of Fluorenones from Benzaldehydes and Aryl Iodides: Dual C-H Functionalizations Using a Transient Directing Group

The first synthesis of substituted fluorenones directly from benzaldehydes and aryl iodides via a Pd(II)-catalyzed C(sp2)-H functionalization cascade is reported. Featuring anthranilic acid as an inexpensive transient directing group, the process is compatible with a variety of benzaldehydes and aryl iodides. A three-step synthesis of the antiviral drug Tilorone was completed in an excellent overall yield (40%), demonstrating the utility of this method.