431-89-0 Usage
Description
1,1,1,2,3,3,3-Heptafluoropropane, also known as HFC 227ea, is a colorless, odorless, and non-flammable liquefied gas that exists as a liquid at room temperature when contained under its own vapor pressure or as a gas when exposed to room temperature and atmospheric pressure. It is non-corrosive, non-irritating, and has a faint ether-like odor in high concentrations.
Uses
Used in Refrigeration and Air Conditioning Industry:
1,1,1,2,3,3,3-Heptafluoropropane is used as a CFC replacement in refrigerants, high-temperature heat pumps, and air-conditioning systems due to its environmentally friendly properties and efficient performance.
Used in Fire Suppression:
1,1,1,2,3,3,3-Heptafluoropropane is used as a fire suppressant because of its non-flammable nature and ability to effectively extinguish fires without causing damage to equipment or the environment.
Used in Pharmaceutical Industry:
1,1,1,2,3,3,3-Heptafluoropropane is used in pharmaceutical aerosols and metered-dose inhalers as a propellant, providing a safe and effective means of delivering medications in the form of inhalable aerosols.
Flammability and Explosibility
Nonflammable
Pharmaceutical Applications
Heptafluoropropane is classified as a hydrofluorocarbon
(HFC) aerosol propellant since the molecule consists only of carbon,
fluorine, and hydrogen atoms. It does not contain any chlorine and
consequently does not affect the ozone layer, nor does it have an
effect upon global warming. It is therefore considered as an
alternative propellant to CFCs for metered-dose inhalers (MDIs).
While some of its physical and chemical properties are known, little
has been published in regard to its use as a replacement for CFCs in
MDIs.
The vapor pressure of heptafluoropropane is somewhat
lower than that of tetrafluoroethane and dichlorodifluoromethane
but considerably higher than the vapor pressure used to formulate
most MDIs.
When heptafluoropropane is used for pharmaceutical
aerosols and MDIs, the pharmaceutical grade must be specified.
Industrial grades may not be suitable due to their impurity profile.
Similarly to tetrafluoroethane, heptafluoropropane is not a good
solvent for medicinal agents or for the commonly used surfactants
and dispersing agents used in the formulation of MDIs.
There are several MDIs formulated with this propellant worldwide
that contain a steroid as the active ingredient.
Safety
Heptafluoropropane is used as a fire extinguisher and is applicable
as a non-CFC propellant in various metered-dose inhalers.
Heptafluoropropane is regarded as nontoxic and nonirritating
when used as directed. No acute or chronic hazard is present when it
is used normally. Inhaling high concentrations of heptafluoropropane
vapors can be harmful and is similar to inhaling vapors of
other propellants. Deliberate inhalation of vapors of heptafluoropropane
can be dangerous and may cause death. The same
labeling required of CFC aerosols would be required for those
containing heptafluoropropane as a propellant (except for the EPA
requirement).
storage
Heptafluoropropane is a nonreactive and stable material. The
liquefied gas is stable when used as a propellant and should be
stored in a metal cylinder in a cool, dry place.
Check Digit Verification of cas no
The CAS Registry Mumber 431-89-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,3 and 1 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 431-89:
(5*4)+(4*3)+(3*1)+(2*8)+(1*9)=60
60 % 10 = 0
So 431-89-0 is a valid CAS Registry Number.
InChI:InChI=1/C3HF7/c4-1(2(5,6)7)3(8,9)10/h1H
431-89-0Relevant articles and documents
Polishchuk et al.
, p. 3933 (1970)
Absolute rates of intermolecular carbon-hydrogen abstraction reactions by fluorinated radicals
Shtarev, Alexander B.,Tian, Feng,Dolbier Jr., William R.,Smart, Bruce E.
, p. 7335 - 7341 (1999)
Using competition kinetic methodology, absolute rate constants for bimolecular hydrogen abstraction from a variety of organic substrates in solution have been obtained for the n-C4H9CF2CF2(·), n-C4F9(·), and i-C3F7(·) radicals. Fluorine substitution substantially increases the reactivity of alkyl radicals with respect to C-H abstraction, with the secondary radical being most reactive. A wide range of substrate reactivities (5200-fold) was observed, with the results being discussed in terms of an interplay of thermodynamic, polar, steric, stereoelectronic, and electrostatic/field effects on the various C-H abstraction transition states. Representative carbon-hydrogen bond dissociation energies of a number of ethers and alcohols have been calculated using DFT methodology.
Unusual conversion of perfluoromethylepoxycyclopentane into a linear β-aminovinylketone by C-C bond cleavage
Barten, Jan A.,Kadyrov, Alexander A.,Roeschenthaler, Gerd-Volker
, p. 101 - 103 (2002)
2,3,3,4,4,5,5-Heptafluoro-1-trifluoromethyl-1,2-epoxycyclopentane reacted with 2-isopropyl-acetophenone imine giving 2,3,3,4,4,5,5-heptafluoro-2-trifluoromethyl-1-(2′-isopropylimino- 2′-phenylethane) cyclopentan-1-ol, which in its turn underwent an intramolecular rearrangement yielding the linear 4,4,5,5,6,6,7,8,8,8-decafluoro-1-isopropylamino-oct-1-en-3-one, being characterized by X-ray structural analysis (triclinic, P-1, a = 920.5(2), b = 1027.9(3), c = 1127.4(3)pm, α = 110.99, β = 105.68°, γ = 96.75°).
METHOD AND APPARATUS FOR CONTINUOUSLY PRODUCING 1,1,1,2,3-PENTAFLUOROPROPANE WITH HIGH YIELD
-
Paragraph 0110-0111, (2014/05/20)
A method and apparatus for method of continuously producing 1,1,1,2,3-pentafluoropropane with high yield is provided. The method includes (a) bringing a CoF3-containing cobalt fluoride in a reactor into contact with 3,3,3-trifluoropropene to produce a CoF2-containing cobalt fluoride and 1,1,1,2,3-pentafluoropropane, (b) transferring the CoF2-containing cobalt fluoride in the reactor to a regenerator and bringing the transferred CoF2-containing cobalt fluoride into contact with fluorine gas to regenerate a CoF3-containing cobalt fluoride, and (c) transferring the CoF3-containing cobalt fluoride in the regenerator to the reactor and employing the transferred CoF3-containing cobalt fluoride in Operation (a). Accordingly, the 1,1,1,2,3-pentafluoropropane can be continuously produced with high yield from the 3,3,3-trifluoropropene using a cobalt fluoride (CoF2/CoF3) as a fluid catalyst, thereby improving the reaction stability and readily adjusting the optimum conversion rate and selectivity.
Coupling reactions of chlorofluoro and perfluoroalkyl iodides
Wlassics, Ivan,Tortelli, Vito
scheme or table, p. 1719 - 1728 (2009/06/05)
Coupling reactions of chlorofluoro- and perfluoroalkyl iodides R f-I with Rf = ClCF2CFCl-(CF2) 3CF2-, ClCF2CFClO(CF2) 3CF2-, ClCF2CFCl-, (CF3) 2CF- , (CF3)2CFCF2CF2- in the presence of a zinc/solvent system give dimers in good yields. Both homodimerizations (one iodide) and heterodimerizations (two different iodides) have been studied. The effect of temperature and solvent is shown. The zinc mediated dechlorination of vicinal chlorine atoms in the dimers afforded terminal alkenes and dienes.