43156-48-5

Basic information

• Product Name: 5-PHENYLTHIO-1,2-DIAMINOBENZENE
• Synonyms: 5-PHENYLTHIO-1,2-DIAMINOBENZENE;4-(phenylthio)benzene-1,2-diamine;3,4-DIAMINODIPHENYLSULFIDE;4-(Phenylthio)-1,2-benzenediamine;4-(Phenylthio)-o-phenylenediamine;4-Phenylsulfenyl-o-phenylenediamine;4-Thiophenoxy-1,2-phenylenediamine
• CAS NO: 43156-48-5
• Molecular Formula: C₁₂H₁₂N₂S
• Molecular Weight: 216.3
• EINECS: 256-122-1
• Product Categories: Benzene derivates
• Mol File: 43156-48-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 441.5°Cat760mmHg
• Flash Point: 220.8°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 5.41E-08mmHg at 25°C
• Refractive Index: 1.707
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.36±0.10(Predicted)
• Stability: Air Sensitive
• CAS DataBase Reference: 5-PHENYLTHIO-1,2-DIAMINOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYLTHIO-1,2-DIAMINOBENZENE(43156-48-5)
• EPA Substance Registry System: 5-PHENYLTHIO-1,2-DIAMINOBENZENE(43156-48-5)

Safety Data

• Hazardous Substances Data: 43156-48-5(Hazardous Substances Data)

Usage

Uses

4-(Phenylthio)-1,2-benzenediamine is used in the synthesis of bis(2-chloroethyl)aminophosphoryl-containing compounds which are potential anticancer agents. It is also used in the synthesis of 2-substituted-2,3-dihyrdro-5-thiophenoxy-1H-1,3,2-benzodiazaphosphole 2-oxides which exhibit antimicrobial activity.

InChI:InChI=1/C12H12N2S/c13-11-7-6-10(8-12(11)14)15-9-4-2-1-3-5-9/h1-8H,13-14H2

Upstream product

• 930-69-8 sodium thiophenolate 
• 54029-45-7 2-nitro-4-thiocyanoaniline 
• 89-63-4 4-Chloro-2-nitroaniline 
• 108-42-9 3-chloro-aniline 
• 5228-61-5 5-bromo-2-nitroaniline 
• 106-37-6 1.4-dibromobenzene 
• 51686-78-3 2,4-dibromonitrobenzene 
• 92114-64-2 2-nitro-4-(phenylthio)aniline 
• 611-06-3 2,4-dichloronitrobenzene 
• 541-73-1 1,3-Dichlorobenzene 
• 43156-47-4 2-nitro-5-phenylthioaniline 
• 5443-33-4 N-(5-chloro-2-nitrophenyl)acetamide 
• 108-98-5 thiophenol 
• 1635-61-6 5-chloro-2-nitroaniline 

Downstream Products

• 43156-47-4 2-nitro-5-phenylthioaniline 
• 43210-67-9 fenbendazole 
• 43210-67-9 Fenbendazole 
• 54394-05-7 1,2-bis-(3-carbomethoxy-2-thioureido)-4-phenylthiobenzene 
• 129165-89-5 [6-(5-Phenylsulfanyl-1H-benzoimidazol-2-ylcarbamoyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester 
• 129165-85-1 4-Acetylamino-3-nitro-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-benzamide 
• 129165-87-3 4-Amino-3-nitro-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-benzamide 
• 125422-50-6 2-(1-Pyrrolidinoacetylamino)-5⁽⁶⁾-phenylsulphonobenzimidazole 
• 125422-36-8 2-Acetamido-5⁽⁶⁾-(3-nitro-5-phenylsulphono)-benzimidazole 
• 125422-44-8 2-Morpholin-4-yl-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-acetamide 
• 125422-47-1 2-(4-Methyl-piperidin-1-yl)-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-acetamide 
• 125422-45-9 2-(2-Methyl-piperidin-1-yl)-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-acetamide 
• 125422-46-0 2-(3-Methyl-piperidin-1-yl)-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-acetamide 
• 125422-40-4 1-(3-Methyl-piperidin-1-yl)-2-(5-phenylsulfanyl-1H-benzoimidazol-2-ylamino)-ethanone 

Relevant articles and documents

Synthetic method of fenbendazole

A synthetic method of fenbendazole belongs to the technical field of insect repellents, and specifically comprises the following steps: carrying out condensation reaction on 5-chloro-2-nitroaniline and a sodium thiophenol aqueous solution in a mixed solution of n-propyl alcohol and water to obtain 5-thiophenyl-2-nitroaniline; carrying out reduction reaction on the 5-thiophenyl-2-nitroaniline in a high-pressure kettle under the catalysis of raney nickel to generate 4-thiophenyl o-phenylenediamine; and mixing the 4-thiophenyl o-phenylenediamine and N-(trichloromethyl) methyl carbamate for a cyclization reaction to obtain fenbendazole; the method has the advantages that conditions are mild, operation is easy and convenient, ammonium chloride can be prevented from being generated in the cyclization process, and the three-waste cost is low; the generation of amine salt is avoided, and the treatment cost of three wastes is greatly reduced; and the yield of the fenbendazole can reach 84.27% to 89.99%, and the purity of the fenbendazole can reach 96.39% to 99.71%.

Fenbendazole production process and production device

The invention discloses a fenbendazole production process and a production device, the production process comprises a nitration reaction, a condensation reaction, a reduction reaction and a cyclization reaction, and finally the fenbendazole is obtained through centrifugation and drying. The production device comprises a plurality of reaction kettles, a distillation device and a distillation recovery device, the reaction kettles are respectively a nitration reaction kettle, a condensation reaction kettle, a cyclization reaction kettle and a reduction reaction kettle, and the nitration reactionkettle, the condensation reaction kettle, the cyclization reaction kettle, the distillation device and the reduction reaction kettle are sequentially communicated through feeding pipes. According to the process, the product purity can be improved; few types of chemical reagents are adopted, and methanol and methylbenzene are recycled so that reagent consumption is reduced, waste is avoided, and the process is economical and environmentally friendly; the process route is simple, the production period is shortened, and the production efficiency is improved; according to the production device, automatic feeding is achieved through the feeding mechanism, the automation degree is high, manual operation is reduced, and efficiency is improved.

A preparation method of curing melanotumor

The invention discloses a preparation method of fenbendazole and provides a brand-new synthesis route of the fenbendazole. The fenbendazole is prepared from m-dichlorobenzene as a starting material through the steps of nitrification, condensation, amination, reduction and cyclization. The preparation method is characterized in that the starting material m-chloroaniline in the existing industrial route is changed to the cheap m-dichlorobenzene; the existing reduction technology with sodium sulfide dihydrate is changed to the clean and high-efficiency reduction technology; and the new synthesis technology is concise and simple, high in efficiency, slight in pollution, high in quality, and suitable to industrial production.