4349-62-6Relevant articles and documents
Synthesis and preliminary biological evaluations of 5'-substituted derivatives of uridine as glycosyltransferase inhibitors
Paszkowska, Jadwiga,Kral, Katarzyna,Bieg, Tadeusz,Nawrot, Urszula,Szeja, Wieslaw,Wandzik, Ilona
, p. 8018 - 8027 (2013)
New derivatives of uridine which contain a β-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1-4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were not
Capsaicine derivatives, preparation method of capsaicine derivatives and application of capsaicine derivatives in preparation of drugs for cardiovascular diseases
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Paragraph 0038-0041, (2020/12/05)
The invention provides capsaicine derivatives, a preparation method of the capsaicine derivatives and an application of the capsaicine derivatives in preparation of drugs for cardiovascular diseases.A compound has a structure as shown in a general formula
Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold
Rotondi, Giulia,Guglielmi, Paolo,Carradori, Simone,Secci, Daniela,De Monte, Celeste,De Filippis, Barbara,Maccallini, Cristina,Amoroso, Rosa,Cirilli, Roberto,Akdemir, Atilla,Angeli, Andrea,Supuran, Claudiu T.
, p. 1400 - 1413 (2019/08/26)
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives.