437611-93-3

Basic information

• Product Name: 2-(2-(3,4,5-trimethoxyphenyl)ethynyl)benzaldehyde
• Synonyms: 2-(2-(3,4,5-trimethoxyphenyl)ethynyl)benzaldehyde
• CAS NO: 437611-93-3
• Molecular Weight: 296.323
• Mol File: 437611-93-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(2-(3,4,5-trimethoxyphenyl)ethynyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(3,4,5-trimethoxyphenyl)ethynyl)benzaldehyde(437611-93-3)
• EPA Substance Registry System: 2-(2-(3,4,5-trimethoxyphenyl)ethynyl)benzaldehyde(437611-93-3)

Safety Data

• Hazardous Substances Data: 437611-93-3(Hazardous Substances Data)

Upstream product

• 53560-33-1 3,4,5-trimethoxyphenylacetylene 
• 25245-29-8 5-iodo-1,2,3-trimethoxybenzene 
• 38846-64-9 2-ethynylbenzaldehyde 
• 77295-62-6 1,1-Dibromo-2-(3',4',5'-trimethoxyphenyl)ethene 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1185881-93-9 (2-(3,4,5-trimethoxyphenethyl)phenyl)methanol 
• 1185881-94-0 2-(3,4,5-trmethoxyphenethyl)benzaldehyde 
• 1185881-56-4 C₂₄H₂₆O₇ 
• 1307781-61-8 (E)-ethyl 3-(2-((3,4,5-trimethoxyphenyl)ethynyl)phenyl)acrylate 
• 1307782-49-5 (2E,4Z)-ethyl 1-oxo-4-(3,4,5-trimethoxyphenyl)-1H-benzo[d]azepine-2-carboxylate 

Relevant articles and documents

A gold(i)-catalyzed intramolecular tandem cyclization reaction of alkylidenecyclopropane-containing alkynes

A novel gold(i)-catalyzed intramolecular tandem cyclization reaction of ortho-(arylethynyl)arenemethylenecyclopropanes provided an efficient approach to prepare functionalized 11H-benzo[a]fluorene derivatives in moderate to good yields. Further transformations as well as applications of the products have been presented and a plausible reaction mechanism has also been proposed on the basis of deuterium labeling and control experiments.

Regio- and stereoselective construction of highly functionalized 3-benzazepine skeletons through ring-opening cycloamination reactions catalyzed by Gold

Ring size under control: Highly functionalized 1-amino- or 1-hydroxy-1H-benzo[d]azepines have been prepared through a gold-catalyzed cyclization of (o-alkynyl)phenyl aziridines with heteronucleophiles. After removal of the phthalimido group, the products can be further transformed into 1H-benzo[d]azepin-1-ones (see scheme; IBX=2-iodoxybenzoic acid, Phth=pthalimido).

Synthesis of substituted isoquinolines by electrophilic cyclization of iminoalkynes

The tert-butylimines of o-(1-alkynyl)benzaldehydes and analogous pyridinecarbaldehydes have been cyclized under very mild reaction conditions in the presence of I2, ICl, PhSeCl, PhSCl, and p-O2-NC6H4SCl to give the corresponding halogen-, selenium-, and sulfur-containing disubstituted isoquinolines and naphthyridines, respectively. This methodology accommodates a variety of iminoalkynes and affords the anticipated heterocycles in moderate to excellent yields. Monosubstituted isoquinolines and naphthyridines have been synthesized by the metal-catalyzed ring closure of these same iminoalkynes. The silver-catalyzed ring closure is highly effective in cyclizing aryl-, alkenyl-, and alkyl-substituted iminoalkynes at 50°C.