437762-12-4

Basic information

• Product Name: (S)-1-phenyl-N-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)ethan-1-amine
• Synonyms: (S)-1-phenyl-N-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)ethan-1-amine
• CAS NO: 437762-12-4
• Molecular Weight: 293.332
• Mol File: 437762-12-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-1-phenyl-N-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)ethan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-phenyl-N-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)ethan-1-amine(437762-12-4)
• EPA Substance Registry System: (S)-1-phenyl-N-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)ethan-1-amine(437762-12-4)

Safety Data

• Hazardous Substances Data: 437762-12-4(Hazardous Substances Data)

Upstream product

• 672906-91-1 (E)-N-(1-(S)-phenylethyl)ethan-1-(4-(trifluoromethyl)phenyl)-1-imine 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 439084-89-6 C₆H₆O₃S*C₁₇H₁₈F₃N 

Downstream Products

• 27190-69-8 1-ethyl-4-(trifluoromethyl)benzene 
• 84499-73-0 (S)-N-[α-ethyl-4-(trifluoromethyl)benzyl]amine 
• 578027-35-7 (R)-N-[α-ethyl-4-(trifluoromethyl)benzyl]amine 
• 439084-89-6 C₆H₆O₃S*C₁₇H₁₈F₃N 

Relevant articles and documents

B(C6F5)3-Catalyzed Asymmetric Reductive Amination of Ketones with Ammonia Borane

The first example of metal-free B(C6F5)3-catalyzed asymmetric reduction amination of ketones with chiral α-methylbenzylamine (α-MBA) using ammonia borane as the reductant is reported. This one-pot method has a broad substrate scope and provides various chiral amines in 81-95% yield with 80-99% de. This protocol was further applied in the total synthesis of cinacalcet.

Process for producing optically active 1-(fluoro- or trifluoromethyl-substituted phenyl) ethylamine and process for purifying same

An optically active 1-(fluoro- or trifluoromethyl-substituted phenyl)ethylamine is produced with high optical purity and in an industrially simple and efficient manner by asymmetrically reducing an optically active imine, obtained by dehydration and conde

Highly regioselective hydrogenolysis of bis(α-methylbenzyl)amine derivatives affected by the trifluoromethyl substituent on the aromatic ring

(Matrix presented) The highly regioselective hydrogenolysis of bis(α-methylbenzyl)amine derivatives proceeded with influence not from the electronic effect but from the steric effect of the trifluoromethyl substituent on the aromatic ring to provide a practical asymmetric synthesis of trifluoromethyl-substituted α-phenylethylamines.