578027-35-7

Basic information

• Product Name: (R)-1-[4-(Trifluoromethyl)phenyl]ethylamine
• Synonyms: (R)-1-(4-(TRIFLUOROMETHYL)PHENYL)ETHANAMINE;(R)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;R-PTF-PEM;(R)-1-[4-(Trifluoromethyl)phenyl]ethylamine 98%;(R)-1-[4-(Trifluoromethyl)phenyl]ethylamine98%;(R)-1-[4-(Trilfuoromethyl)phenyl]ethylamine;Benzenemethanamine, α-methyl-4-(trifluoromethyl)-, (αR)-;(1R)-1-[4-(Trifluoromethyl)phenyl]ethylamine
• CAS NO: 578027-35-7
• Molecular Formula: C₉H₁₀F₃N
• Molecular Weight: 189.18
• Product Categories: intermediaes
• Mol File: 578027-35-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 168.6°C at 760 mmHg
• Flash Point: 55.8°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 1.61mmHg at 25°C
• Refractive Index: 1.508
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.56±0.10(Predicted)
• CAS DataBase Reference: (R)-1-[4-(Trifluoromethyl)phenyl]ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-[4-(Trifluoromethyl)phenyl]ethylamine(578027-35-7)
• EPA Substance Registry System: (R)-1-[4-(Trifluoromethyl)phenyl]ethylamine(578027-35-7)

Safety Data

• Hazard Codes: Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• Hazardous Substances Data: 578027-35-7(Hazardous Substances Data)

Usage

General Description

(R)-1-[4-(Trifluoromethyl)phenyl]ethylamine, also known as R-tfmepa, is a chemical compound with the molecular formula C10H12F3N. It is a colorless liquid at room temperature and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. (R)-1-[4-(Trifluoromethyl)phenyl]ethylamine belongs to the class of aromatic amines and contains a trifluoromethyl group attached to a phenyl ring. R-tfmepa has potential applications in the development of drugs and other industrial processes due to its unique chemical properties and structure. Its use should be carefully regulated and handled under appropriate safety measures due to its potential health hazards and reactivity.

InChI:InChI=1/C8H5F3OS/c9-8(10,11)13-7-4-2-1-3-6(7)5-12/h1-5H

Upstream product

• 866540-38-7 N-(1-(4-trifluoromethyl)ethylidene)diphenylphosphinamide 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 1737-26-4 1-(4-trifluorophenyl)ethanol 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 911372-68-4 (R_S)-2-methyl-N-((R)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide 
• 437762-12-4 (S)-1-phenyl-N-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)ethan-1-amine 
• 444643-05-4 ((S)-1-Phenyl-ethyl)-[(R)-1-(4-trifluoromethyl-phenyl)-ethyl]-amine 
• 626244-16-4 (R)-1-(4-trifluoromethylphenyl)ethylamine benzenesulfonate 
• 626244-14-2 (R)-1-(4-trifluoromethylphenyl)ethylamine phthalate 
• 107496-43-5 1-(4-(trifluoromethyl)phenyl)ethan-1-one O-methyl oxime 
• 15996-84-6 1-(4-trifluoromethylphenyl)ethylamine 
• 581812-92-2 (R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide 
• 721446-00-0 (R)-N-(1-(4-trifluoromethylphenyl)ethyl) bis(3,5-dimethylphenyl)phosphinamide 

Downstream Products

• 1092578-11-4 (R)-N-benzyl-N-[α-methyl-4-(trifluoromethyl)benzyl]amine 

Relevant articles and documents

Asymmetric reduction method of nitrogen-phosphonyl protected imine

The invention discloses an asymmetric reduction method of nitrogen phosphonyl protective imine. The nitrogen phosphonyl protective imine is reduced into chiral amine in a hydrogen atmosphere under theaction of a metal catalyst and alkali, and the metal catalyst is prepared from a metal iridium complex and a nitrogen-phosphorus chiral ligand. The method provided by the invention has the characteristics of high enantioselectivity, high yield and high conversion number (TON). The method can be used for synthesizing various substituted chiral amines, can be used as an important intermediate for preparing various medicines, and has important significance for industrial production of medicines.

Asymmetric Synthesis of Chiral Primary Amines by Ruthenium-Catalyzed Direct Reductive Amination of Alkyl Aryl Ketones with Ammonium Salts and Molecular H2

A ruthenium/C3-TunePhos catalytic system has been identified for highly efficient direct reductive amination of simple ketones. The strategy makes use of ammonium acetate as the amine source and H2 as the reductant and is a user-friendly and operatively simple access to industrially relevant primary amines. Excellent enantiocontrol (>90% ee for most cases) was achieved with a wide range of alkyl aryl ketones. The practicability of this methodology has been highlighted by scalable synthesis of key intermediates of three drug molecules. Moreover, an improved synthetic route to the optimal diphosphine ligand C3-TunePhos is also presented.

Trading N and O. Part 3: Synthesis of 1,2,3,4-tetrahydroisoquinolines from α-hydroxy-β-amino esters

A range of enantiopure 1,2,3,4-tetrahydroisoquinolines have been prepared directly from α-hydroxy-β-amino esters. Activation of the α-hydroxy group upon treatment with Tf2O and 2,6-di-tert-butyl-4-methylpyridine promotes aziridinium formation,