443-82-3

Basic information

• Product Name: 3-FLUORO-O-XYLENE
• Synonyms: 3-fluoro-o-xylen;Benzene, 1-fluoro-2,3-dimethyl-;o-Xylene, 3-fluoro-;3-FLUORO-1,2-XYLENE;3-FLUORO-1,2-DIMETHYL BENZENE;3-FLUORO-O-XYLENE;1,2-DIMETHYL-3-FLUOROBENZENE;1-FLUORO-2,3-DIMETHYLBENZENE
• CAS NO: 443-82-3
• Molecular Formula: C₈H₉F
• Molecular Weight: 124.16
• EINECS: 207-140-3
• Product Categories: Halogen toluene
• Mol File: 443-82-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 148-152 °C(lit.)
• Flash Point: 97 °F
• Appearance: colorless clear liquid
• Density: 0.99 g/mL at 25 °C(lit.)
• Vapor Pressure: 4.77mmHg at 25°C
• Refractive Index: n20/D 1.486(lit.)
• Storage Temp.: Flammables area
• Water Solubility: Insoluble in water.
• BRN: 2040955
• CAS DataBase Reference: 3-FLUORO-O-XYLENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-O-XYLENE(443-82-3)
• EPA Substance Registry System: 3-FLUORO-O-XYLENE(443-82-3)

Safety Data

• Hazard Codes: F,Xi
• Statements: 10-37
• Safety Statements: 16-24/25
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• RTECS: ZE4560000
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 443-82-3(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

InChI:InChI=1/C8H9F/c1-6-4-3-5-8(9)7(6)2/h3-5H,1-2H3

Upstream product

• 1412414-17-5 potassium (2,3-dimethylphenyl)trifluoroborate 
• 36018-19-6 2,3-dimethylphenyl chloroformate 
• 120-82-1 1,2,4-Trichlorobenzene 
• 62590-16-3 α,α'-dibromo-3-fluoro-o-xylene 
• 95-47-6 o-xylene 
• 87-59-2 2,3-Dimethylaniline 

Downstream Products

• 161747-14-4 3-fluorobenzene-1,2-dicarbaldehyde 
• 66354-67-4 4-methyl-2-phenyl-1H-indole 
• 1092448-48-0 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-4-fluoro-indan-2-carboxylic acid ethyl ester 
• 1092445-89-0 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-4-fluoro-indan-2-carboxylic acid 
• 363134-38-7 2-fluoro-3,4-dimethylbenzaldehyde 
• 685565-16-6 2-benzyl-4-fluoroisoindoline 
• 52872-60-3 (2-fluoro-3,4-dimethyl-phenyl)-(5-nitro-thiazol-2-yl)-methanone 
• 52548-00-2 1-bromo-4-fluoro-2,3-dimethylbenzene 
• 1737-68-4 2,3-dimethyl-4-fluoroaniline 
• 652-39-1 3-fluorophthalic anhydride 
• 62590-16-3 α,α'-dibromo-3-fluoro-o-xylene 

Relevant articles and documents

Silver-mediated fluorination of potassium aryltrifluoroborates with Selectfluor Dedicated to Professor Andrea Vasella on the occasion of his 71st birthday

A simple and practical procedure for the silver-mediated fluorination of aryl- and heteroaryltrifluoroborates with electrophilic fluorine from Selectfluor and LiOH·H2O is presented. The reaction procedure is simple and easy to set up, the process produces fluorinated arenes and heteroarenes in good to excellent yields and a wide range of electronically and structurally diverse substrates are tolerated.

Process for the preparation of fluoro compounds from the corresponding amines

Compounds containing a primary amino group are converted into compounds containing a fluorine atom in place of the amino group by reaction of the amino compound with hydrogen fluoride and a nitrosating reagent under the influence of ultrasound or microwaves.

Process for preparing o-alkylfluorobenzenes

o-Alkylfluorobenzenes are advantageously prepared by heating the corresponding chloroformates to from 70° to 200° C. in the liquid phase in the presence of hydrogen fluoride and in the presence of an inert diluent other than a halogenated alkane.