62590-16-3

Basic information

• Product Name: 1,2-bis(bromomethyl)-3-fluorobenzene
• Synonyms: 1,2-bis(bromomethyl)-3-fluorobenzene
• CAS NO: 62590-16-3
• Molecular Formula: C₈H₇Br₂F
• Molecular Weight: 281.9475832
• Mol File: 62590-16-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 267 °C at 760 mmHg
• Flash Point: 115.2 °C
• Appearance: /
• Density: 1.847 g/cm³
• Vapor Pressure: 0.0138mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 1,2-bis(bromomethyl)-3-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis(bromomethyl)-3-fluorobenzene(62590-16-3)
• EPA Substance Registry System: 1,2-bis(bromomethyl)-3-fluorobenzene(62590-16-3)

Safety Data

• Hazardous Substances Data: 62590-16-3(Hazardous Substances Data)

Usage

General Description

1,2-bis(bromomethyl)-3-fluorobenzene is a chemical compound with the molecular formula C8H7Br2F. It is a benzene derivative that contains two bromomethyl groups and one fluorine atom attached to the benzene ring. 1,2-bis(bromomethyl)-3-fluorobenzene is commonly used as a reagent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is a colorless liquid with a high boiling point, making it suitable for use in high-temperature reactions. 1,2-bis(bromomethyl)-3-fluorobenzene is also known for its potential neurotoxic and mutagenic properties, and proper safety measures should be taken when handling this chemical.

InChI:InChI=1/C8H7Br2F/c9-4-6-2-1-3-8(11)7(6)5-10/h1-3H,4-5H2

Upstream product

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Downstream Products

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• 113600-16-1 1,2-bis<(triphenylphosphonio)methyl>-3-fluorobenzene dibromide 

Relevant articles and documents

Isosteres of ester derived glucose uptake inhibitors

Glucose transporters (GLUTs) facilitate glucose uptake and are overexpressed in most cancer cells. Inhibition of glucose transport has been shown to be an effective method to slow the growth of cancer cells both in vitro and in vivo. We have previously reported on the anticancer activity of an ester derived glucose uptake inhibitor. Due to the hydrolytic instability of the ester linkage we have prepared a series of isosteres of the ester moiety. Of all of the isosteres prepared, the amine linkage showed the most promise. Several additional analogues of the amine-linked compounds were also prepared to improve the overall activity.

RHO KINASE INHIBITORS

The invention provides novel inhibitors of ROCK1 and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCK1 and/or ROCK2. The present invention includes pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier and/or diluents. The present invention includes compositions comprising a substantially pure compound of the invention and a pharmaceutically acceptable salt, steroisomer, or hydrate thereof: and a pharmaceutically acceptable excipient and/or diluents.

NOVEL CYCLIC BORONATE INHIBITORS OF HCV REPLICATION

Compounds of formula (I) or a salt thereof are provided; wherein R1, R2, R3, R4, R6, R8, R20, R30, Y, Z and n are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicaments for treating viral infection, especially HCV infection are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.