443883-07-6

Basic information

• Product Name: N-{4-[(3-fluorobenzyloxy)]-chlorophenyl}-6-[2-({[2-(methanesulphonyl)ethyl]-[trifluoroacetyl]amino}methyl)-1,3-thiazol-4-yl]-(quinazolin-4-yl)-amine
• Synonyms: N-{4-[(3-fluorobenzyloxy)]-chlorophenyl}-6-[2-({[2-(methanesulphonyl)ethyl]-[trifluoroacetyl]amino}methyl)-1,3-thiazol-4-yl]-(quinazolin-4-yl)-amine
• CAS NO: 443883-07-6
• Molecular Weight: 694.13
• Mol File: 443883-07-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-{4-[(3-fluorobenzyloxy)]-chlorophenyl}-6-[2-({[2-(methanesulphonyl)ethyl]-[trifluoroacetyl]amino}methyl)-1,3-thiazol-4-yl]-(quinazolin-4-yl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-{4-[(3-fluorobenzyloxy)]-chlorophenyl}-6-[2-({[2-(methanesulphonyl)ethyl]-[trifluoroacetyl]amino}methyl)-1,3-thiazol-4-yl]-(quinazolin-4-yl)-amine(443883-07-6)
• EPA Substance Registry System: N-{4-[(3-fluorobenzyloxy)]-chlorophenyl}-6-[2-({[2-(methanesulphonyl)ethyl]-[trifluoroacetyl]amino}methyl)-1,3-thiazol-4-yl]-(quinazolin-4-yl)-amine(443883-07-6)

Safety Data

• Hazardous Substances Data: 443883-07-6(Hazardous Substances Data)

Upstream product

• 202197-25-9 {4-[(3-fluorobenzyl)oxy]phenyl}amine 
• 443882-99-3 3-chloro-4-(3-fluorobenzyloxy)nitrobenzene 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 619-08-9 2-chloro-4-nitrophenol 
• 320337-22-2 N-((4-(3-fluorobenzyloxy)-chlorophenyl)-6-(1-ethoxyethenyl)-quinazolin-4-yl)-amine 
• 202197-26-0 3-chloro-4-(3-fluorobenzyloxy)aniline 
• 552334-87-9 N-cyanomethyl-2,2,2-trifluoro-N-(2-methanesulfonyl-ethyl)-acetamide 
• 552334-86-8 N-cyanomethyl-2,2,2-trifluoro-N-(2-methylsulfanyl-ethyl)-acetamide 
• 552334-85-7 (2-methylsulfanyl-ethylamino)-acetonitrile 
• 231278-20-9 N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine 
• 98556-31-1 4-chloro-6-iodoquinazoline 
• 231278-74-3 N-(trifluoroacetyl)-N-(methanesulphonylethyl)-aminomethylthioamide 
• 443883-09-8 N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-(6-(2-bromoethanone)-quinazolin-4-yl)-amine 

Downstream Products

• 388082-81-3 (4-(3-fluoro-benzyloxy)-3-chlorophenyl)-(6-(2-((2-methanesulphonyl-ethylamino)methyl)-thiazol-4-yl)-quinazolin-4-yl)-amine 

Relevant articles and documents

CANCER TREATMENT METHOD

A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.

Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-Thiazolylquinazolines

We have identified a novel class of 6-thiazolylquinazolines as potent and selective inhibitors of both ErbB-2 and EGFR tyrosine kinase activity, with IC50 values in the nanomolar range. These compounds inhibited the growth of both EGFR (HN5) and ErbB-2 (BT474) over-expressing human tumor cell lines in vitro. Using xenograft models of the same cell lines, we found that the compounds given orally inhibited in vivo tumor growth significantly compared with control animals.