443883-09-8

Basic information

• Product Name: N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-(6-(2-bromoethanone)-quinazolin-4-yl)-amine
• Synonyms: N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-(6-(2-bromoethanone)-quinazolin-4-yl)-amine
• CAS NO: 443883-09-8
• Molecular Weight: 500.754
• Mol File: 443883-09-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-(6-(2-bromoethanone)-quinazolin-4-yl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-(6-(2-bromoethanone)-quinazolin-4-yl)-amine(443883-09-8)
• EPA Substance Registry System: N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-(6-(2-bromoethanone)-quinazolin-4-yl)-amine(443883-09-8)

Safety Data

• Hazardous Substances Data: 443883-09-8(Hazardous Substances Data)

Upstream product

• 98556-31-1 4-chloro-6-iodoquinazoline 
• 202197-25-9 {4-[(3-fluorobenzyl)oxy]phenyl}amine 
• 443882-99-3 3-chloro-4-(3-fluorobenzyloxy)nitrobenzene 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 619-08-9 2-chloro-4-nitrophenol 
• 202197-26-0 3-chloro-4-(3-fluorobenzyloxy)aniline 
• 231278-20-9 N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine 
• 320337-22-2 N-((4-(3-fluorobenzyloxy)-chlorophenyl)-6-(1-ethoxyethenyl)-quinazolin-4-yl)-amine 

Downstream Products

• 320337-33-5 (4-(3-fluorobenzyloxy)-3-chlorophenyl)-(6-(2-(2-cyano-methyly)-thiazol-4-yl)-quinazolin-4-yl)-amine 
• 388082-81-3 (4-(3-fluoro-benzyloxy)-3-chlorophenyl)-(6-(2-((2-methanesulphonyl-ethylamino)methyl)-thiazol-4-yl)-quinazolin-4-yl)-amine 
• 443883-07-6 N-{4-[(3-fluorobenzyloxy)]-chlorophenyl}-6-[2-({[2-(methanesulphonyl)ethyl]-[trifluoroacetyl]amino}methyl)-1,3-thiazol-4-yl]-(quinazolin-4-yl)-amine 

Relevant articles and documents

CANCER TREATMENT METHOD

A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.

Anilinoquinazolines as protein tyrosine kinase inhibitors

Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein tyrosine kinase inhibition.