444-27-9 Usage
Description
Thiazolidine-4-carboxylic acid is a sulfur-containing amino acid derivative of Proline, a cyclic nonessential amino acid. In this compound, the methylene group at position 4 of Proline is replaced by a sulfur atom, resulting in a unique structure with potential applications in various fields.
Uses
1. Used in Pharmaceutical Industry:
Thiazolidine-4-carboxylic acid is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
2. Used in Antineoplastic Research:
Thiazolidine-4-carboxylic acid is used as a research molecule with potential antineoplastic activities. It acts on the cell membrane of tumor cells, causing reverse transformation to normal cells, which can be beneficial in the development of novel cancer treatments.
3. Used in Drug Delivery Systems:
Thiazolidine-4-carboxylic acid can be employed in the development of drug delivery systems, where its unique structure may enhance the delivery, bioavailability, and therapeutic outcomes of various pharmaceutical compounds.
4. Used in Chemical Synthesis:
Thiazolidine-4-carboxylic acid serves as an important intermediate in the synthesis of various organic compounds, including those with potential applications in the chemical, pharmaceutical, and materials science industries.
Originator
Hepaldine,Riker,France,1964
Manufacturing Process
Cysteine is first dissolved in distilled water which has been freed of oxygen by
boiling. Formaldehyde of 30% (w/v) concentration is added while stirring and
the temperature of the mixture rises, while the thiazolidine carboxylic acid
begins crystallizing. The stirring is continued for 2 hours after which ethyl
alcohol of 95% (w/v) concentration is added to induce further crystallization.
The mixture is left to stand for 24 hours at 4°C. The mixture is then filtered
with retention of a crude product, which is purified by recrystallization from
boiling distilled water. The crystals are then dried at about 40°C. The free acid
is then converted to the sodium salt with NaOH.
Therapeutic Function
Hepatoprotectant, Choleretic
Check Digit Verification of cas no
The CAS Registry Mumber 444-27-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,4 and 4 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 444-27:
(5*4)+(4*4)+(3*4)+(2*2)+(1*7)=59
59 % 10 = 9
So 444-27-9 is a valid CAS Registry Number.
InChI:InChI=1/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)
444-27-9Relevant articles and documents
PROCESS FOR PURIFYING (METH)ACRYLIC ACID
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Page/Page column 7-8, (2014/10/03)
A process for producing a grade of (meth)acrylic acid having residual formaldehyde levels of under 100 parts per million.
EFFICIENT SYNTHESIS OF CHELATORS FOR NUCLEAR IMAGING AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS
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Page/Page column 95-96, (2008/06/13)
Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR THEIR PREPARATION
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Page/Page column 45, (2008/06/13)
The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: (I) wherein Y is -S(O)m, -CH2-, CHF, or -CF2; m is 0, 1, or 2; X is a bond, C1-C5 alkyl (e.g., -CH2-), or -C(=0)-; the dotted line [----] in the carbocyclic ring represents an optional double bond; R1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroarylalkyl, CN, -COOR3, CONR3R4, -OR3, -NR3R4, or NR3COR3; R2 is hydrogen, cyano, COOH, or an isostere of a carboxylic acid (such as SO3H, CONOH, B(OH)2, PO3R3R4, SO2NR3R4, tetrazole, -COOR3, -CONR3R4, NR3COR4, or -COOCOR3).
