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4451-86-9

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4451-86-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4451-86-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,5 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4451-86:
(6*4)+(5*4)+(4*5)+(3*1)+(2*8)+(1*6)=89
89 % 10 = 9
So 4451-86-9 is a valid CAS Registry Number.

4451-86-9Relevant articles and documents

Immunopotentiator agents

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Page column 8, (2010/02/05)

Novel compounds and methods for preparing same, immunopotentiating compositions, and a method for potentiating the immune system of a host animal. The method comprises administering to the animal an effective amount of an immunopotentiating compound of Formula I or Formula II, or a physiologically acceptable salt.

The search for TCP analogues binding to the low affinity PCP receptor sites in the rat cerebellum

Hamon, Jacques,Espaze, Florence,Vignon, Jacques,Kamenka, Jean-Marc

, p. 125 - 135 (2007/10/03)

With the aim of obtaining selective ligands of the low affinity binding sites of [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine ([3H]TCP) in the rat cerebellum, oxygen and sulfur atoms were introduced in the TCP structure and derivatives to obtain analogues with a lowered lipophilicity. These compounds, and others already obtained, were assayed comparatively to determine their affinities for three sites labeled with [3H]TCP: one in the forebrain, the originally described PCP receptor, and two in the rat cerebellum. Lowering the lipophilicity and modifying the hetero-aromatic moiety yielded some ligands with increased affinity for the low affinity sites in the rat cerebellum and decreased affinity for the high affinity sites in the forebrain. Particularly, two compounds displaying both a high affinity and a good selectivity might be valuable tools to elucidate the pharmacology of the low affinity PCP sites labeled with [3H]TCP in the rat cerebellum.

Compounds affecting the central nervous system. I. 4-Piperidones and related compounds.

Ganellin,Spickett

, p. 619 - 625 (2007/10/04)

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