4475-28-9Relevant articles and documents
Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A
Taylor, Kimberly S.,Zhang, Chen,Glukhov, Evgenia,Gerwick, William H.,Suyama, Takashi L.
supporting information, p. 865 - 870 (2021/04/02)
Laucysteinamide A (4) is a marine natural product isolated from the cyanobacterium Caldora penicillata and contains structural motifs found in promising cancer drug leads. The first total synthesis of 4 and its analogues was achieved, which also enabled a concise formal synthesis of somocystinamide A (3), a dimeric congener of 4 that previously showed extremely potent antiproliferative activities. This work provides further insights on structure-activity relationships in this class of natural products.