52355-51-8Relevant articles and documents
Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A
Taylor, Kimberly S.,Zhang, Chen,Glukhov, Evgenia,Gerwick, William H.,Suyama, Takashi L.
, p. 865 - 870 (2021)
Laucysteinamide A (4) is a marine natural product isolated from the cyanobacterium Caldora penicillata and contains structural motifs found in promising cancer drug leads. The first total synthesis of 4 and its analogues was achieved, which also enabled a concise formal synthesis of somocystinamide A (3), a dimeric congener of 4 that previously showed extremely potent antiproliferative activities. This work provides further insights on structure-activity relationships in this class of natural products.
Polyanion inhibitors of human immunodeficiency virus. Part IV. - Polymerized anionic surfactants : Influence of the density and distribution of anionic groups on the antiviral activity
Leydet, Alain,Barthelemy, Philippe,Boyer, Bernard,Lamaty, Gerard,Roque, Jean-Pierre,Witvrouw, Myriam,De Clercq, Erik
, p. 397 - 402 (2007/10/03)
The synthesis of a series of new polyanions, via γ-polymerization, of ω-unsaturated multi-charged anionic surfactants, has been realized. These polyanions were evaluated for their activity against HIV-1. All tested compounds proved active without presenting toxicity to the host cells (CEM-4 or MT-4).
