4498-74-2

Basic information

• Product Name: 3-(PHENYLMETHYL)-1H-INDAZOLE
• Synonyms: 3-(PHENYLMETHYL)-1H-INDAZOLE;3-Benzyl-1H-indazole
• CAS NO: 4498-74-2
• Molecular Formula: C₁₄H₁₂N₂
• Molecular Weight: 208.25848
• Mol File: 4498-74-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 113-115 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
• Boiling Point: 277.6°C at 760 mmHg
• Flash Point: 110.3°C
• Appearance: /
• Density: 1.193g/cm³
• Vapor Pressure: 0.00447mmHg at 25°C
• Refractive Index: 1.679
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 14.45±0.40(Predicted)
• CAS DataBase Reference: 3-(PHENYLMETHYL)-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(PHENYLMETHYL)-1H-INDAZOLE(4498-74-2)
• EPA Substance Registry System: 3-(PHENYLMETHYL)-1H-INDAZOLE(4498-74-2)

Safety Data

• Hazardous Substances Data: 4498-74-2(Hazardous Substances Data)

Usage

General Description

3-(Phenylmethyl)-1H-indazole is a chemical compound belonging to the class of indazoles, which are organic heterocyclic compounds. It is a derivative of indazole, a bicyclic compound containing a five-membered ring fused to a six-membered ring. The "3-(phenylmethyl)" group attached to the indazole core indicates that a phenylmethyl substituent is present at the 3-position of the indazole ring. 3-(PHENYLMETHYL)-1H-INDAZOLE is of interest for its potential pharmaceutical and research applications, as indazoles have been investigated for their various biological activities, including their potential use as therapeutic agents in conditions such as cancer and inflammation. Further research on 3-(phenylmethyl)-1H-indazole may reveal its specific biological activities and potential for drug development.

InChI:InChI=1/C14H12N2/c1-2-6-11(7-3-1)10-14-12-8-4-5-9-13(12)15-16-14/h1-9H,10H2,(H,15,16)

Upstream product

• 51463-49-1 dimethyl 1-diazo-2-phenylethylphosphonate 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 21375-88-2 1-bromo-2-(phenylethenyl)benzene 
• 1010690-94-4 1-(2-aminophenyl)-2-phenylethanone oxime 
• 26211-73-4 (2-methyl-1H-indol-3-yl)phenylmethanone 
• 95-20-5 2-methyl-1H-indole 
• 80749-42-4 2-azidophenyl benzyl ketone 
• 89346-69-0 2-(2-phenylethyl)benzenediazonium tetrafluoroborate 
• 98-88-4 benzoyl chloride 
• 19988-04-6 N-(2-(2-phenylacetyl)phenyl)acetamide 

Downstream Products

• 80749-49-1 2-amino-3-benzylindazole 

Relevant articles and documents

Switchable Synthesis of 3-Substituted 1H-Indazoles and 3,3-Disubstituted 3H-Indazole-3-phosphonates Tuned by Phosphoryl Groups

3-Alkyl/aryl-1H-indazoles and 3-alkyl/aryl-3H-indazole-3-phosphonates were synthesized efficiently through a 1,3-dipolar cycloaddition reaction between α-substituted α-diazomethylphosphonates and arynes under simple reaction conditions. The product distribution was controlled by the phosphoryl group, which acted both as a tuning group and a traceless group in the reaction.

The preparation of indazoles via metal free intramolecular electrophilic amination of 2-aminophenyl ketoximes

-

A practical, metal-free synthesis of 1H-Lndazoles

The synthesis of 1H-indazoles is achieved from o-aminobenzoximes by the selective activation of the oxime in the presence of the amino group. The reaction occurs with a variety of substituted o-aminobenzoximes using a slight excess of methanesulfonyl chloride and triethylamine at 0-23 °C and is amenable to scale-up. The synthesis of 1 H-indazoles under these conditions is extremely mild compared with previous synthetic approaches and affords the desired compounds in good to excellent yields.