450839-23-3

Basic information

• Product Name: 5-[1-(4-Cyanophenyl)-1-(1-methyl-1H-imidazol-5-yl)methoxymethyl]-6-(2,2-difluoro-1,3-benzodioxol-5-yl)pyridine-2-carbonitrile
• Synonyms: A-373857
• CAS NO: 450839-23-3
• Molecular Formula: C₂₆H₁₇F₂N₅O₃
• Molecular Weight: 485.45389
• Mol File: 450839-23-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-[1-(4-Cyanophenyl)-1-(1-methyl-1H-imidazol-5-yl)methoxymethyl]-6-(2,2-difluoro-1,3-benzodioxol-5-yl)pyridine-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[1-(4-Cyanophenyl)-1-(1-methyl-1H-imidazol-5-yl)methoxymethyl]-6-(2,2-difluoro-1,3-benzodioxol-5-yl)pyridine-2-carbonitrile(450839-23-3)
• EPA Substance Registry System: 5-[1-(4-Cyanophenyl)-1-(1-methyl-1H-imidazol-5-yl)methoxymethyl]-6-(2,2-difluoro-1,3-benzodioxol-5-yl)pyridine-2-carbonitrile(450839-23-3)

Safety Data

• Hazardous Substances Data: 450839-23-3(Hazardous Substances Data)

Upstream product

• 190903-71-0 (2,2-difluoro-1,3-benzodioxol-5-yl)boronic acid 
• 450844-31-2 6-bromo-5-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)pyridine-2-carbonitrile 
• 588731-33-3 6-bromo-5-bromomethyl-pyridine-2-carbonitrile 
• 450844-27-6 6-bromo-5-methylpyridine-2-carbonitrile 
• 371765-91-2 4-(hydroxy(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile 
• 105-07-7 4-cyanobenzaldehyde 
• 19230-57-0 2-bromo-3-methylpyridine 1-oxide 
• 3430-17-9 2-bromo-3-picoline 

Relevant articles and documents

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability

A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics.

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.