4519-78-2

Basic information

• Product Name: benzyl(diethyl)phosphine oxide
• Synonyms: benzyl(diethyl)phosphine oxide
• CAS NO: 4519-78-2
• Molecular Weight: 196.229
• Mol File: 4519-78-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: benzyl(diethyl)phosphine oxide(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl(diethyl)phosphine oxide(4519-78-2)
• EPA Substance Registry System: benzyl(diethyl)phosphine oxide(4519-78-2)

Safety Data

• Hazardous Substances Data: 4519-78-2(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 686-69-1 diethylchlorophosphine 
• 53772-44-4 benzyloxydiphenylphosphine 
• 762-04-9 Diethyl phosphonate 
• 2386-64-3 ethylmagnesium chloride 
• 100-39-0 benzyl bromide 
• 23666-92-4 triethylbenzyl phosphonium chloride 
• 74-96-4 ethyl bromide 
• 100-44-7 benzyl chloride 
• 41268-70-6 diethyl-benzyl-phosphine 
• 7697-37-2 nitric acid 

Downstream Products

• 103-30-0 (E)-1,2-diphenyl-ethene 
• 813-76-3 diethylphosphinic acid 
• 41268-70-6 diethyl-benzyl-phosphine 

Relevant articles and documents

Ph2PI as a reduction/phosphination reagent: Providing easy access to phosphine oxides

The reaction of aldehydes with Ph2PI provides a facile way to the synthesis of pentavalent phosphine compounds with moderate to good yields.

Trimethylsilyl halide-promoted Michaelis-Arbuzov rearrangement

(Matrix presented) We describe a new, straightforward, and easy-to-handle method for achieving an unprecedented trimethylsilyl halide-catalyzed Michaelis-Arbuzov-like rearrangement. This rearrangement occurs at temperatures from room temperature to 80°C and does not require addition of any alkyl halide. The scope and limitations of this new reaction are explored, as well as its mechanism.

Anilide derivative, production and use thereof

This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.