454-15-9

Basic information

• Product Name: 2-BROMOMETHYL-1-FLUORO-4-NITROBENZENE
• Synonyms: 2-BROMOMETHYL-1-FLUORO-4-NITROBENZENE;2-Fluoro-5-nitrobenzylbromide
• CAS NO: 454-15-9
• Molecular Formula: C₇H₅BrFNO₂
• Molecular Weight: 234.02
• Mol File: 454-15-9.mol
• Article Data: 16

Chemical Properties

• Melting Point: 74-76 °C
• Boiling Point: 303.369 °C at 760 mmHg
• Flash Point: 137.273 °C
• Appearance: /
• Density: 1.734 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BROMOMETHYL-1-FLUORO-4-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOMETHYL-1-FLUORO-4-NITROBENZENE(454-15-9)
• EPA Substance Registry System: 2-BROMOMETHYL-1-FLUORO-4-NITROBENZENE(454-15-9)

Safety Data

• Hazardous Substances Data: 454-15-9(Hazardous Substances Data)

Usage

General Description

2-BROMOMETHYL-1-FLUORO-4-NITROBENZENE is a compound with the molecular formula C7H5BrFNO2. It is a derivative of benzene with a bromine atom, a fluorine atom, and a nitro group attached to different carbon atoms. This chemical is mainly used as an intermediate for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in the manufacturing of dyes and pigments, as well as in organic synthesis processes. Additionally, it is known to exhibit moderate toxicity and should be handled and stored with appropriate precautions.

Upstream product

• 446-48-0 o-fluorobenzyl bromide 
• 455-88-9 5-nitro-2-fluorotoluene 
• 34241-39-9 azobisisobutyronitrile 
• 63878-73-9 (2-fluoro-5-nitrophenyl)methanol 

Downstream Products

• 16225-13-1 Acetamino-<2-fluor-5-nitro-benzyl>-malonsaeure-diethylester 
• 697305-63-8 1-(2-fluoro-5-nitrophenyl)-N,N-dimethylmethanamine 
• 637335-61-6 2,2-dimethyl-propionic acid 8-(4-acetylamino-benzyl)-3-butyl-1-(2-fluoro-5-nitro-benzyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester 
• 1023002-37-0 methyl 6-nitro-2-phenyl-4H-1-benzopyran-3-carboxylate 
• 1023002-45-0 2-methyl-6-nitro-3-(diphenylphosphinoyl)-4H-1-benzopyran 
• 1023002-48-3 3-cyano-6-nitro-2-phenyl-4H-1-benzopyran 
• 1023002-49-4 3-benzoyl-6-nitro-2-phenyl-4H-1-benzopyran 
• 1023002-40-5 2-methyl-6-nitro-3-(phenylsulfonyl)-4H-1-benzopyran 
• 1021389-09-2 di-tert-butyl 2-(2-fluoro-5-nitrobenzyl)-1,3-propanedioate 
• 1000339-92-3 2-(2-fluoro-5-nitrophenyl)acetonitrile 
• 1048970-99-5 tert-butyl (+/-)-2-(2-fluoro-5-nitrobenzyl)acetoacetate 
• 1138471-25-6 1-(2-fluoro-5-nitro-benzyl)-1H-imidazole 
• 260541-00-2 tert-butyl-(2-fluoro-5-nitro-benzyl)amine 
• 1093183-46-0 1-fluoro-2-(methoxymethyl)-4-nitrobenzene 

Relevant articles and documents

(PYRIDIN-2-YL)AMINE DERIVATIVES AS TGF-BETA R1 (ALK5) INHIBITORS FOR THE TREATMENT OF CANCER

The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder associated with ΤGFβR1 activity, such as a cancer or fibrosis. The invention provides compounds of Formula (I) and Formula (II) as further described herein having an acidic moiety that enhances tissue specificity for targeted tissues and organs. The invention includes pharmaceutical compositions, pharmaceutical combinations, and methods of use of these compounds for treating conditions including cancer or fibrosis.

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula (I): wherein, A, C, D, X, and Y have any of the values defined in the specification, and salts thereof. The compounds are SIRT2 inhibitors and are useful for treating SIRT2 associated conditions.

METHOD FOR PRODUCING SUBSTITUTED PYRIDIN-2-ONE

The present invention relates to a process for the preparation of substituted 3-(2-hydroxyethyl)-1-[4-nitrophenyl]pyridin-2(1H)-ones which serve as important intermediate compounds for producing drugs.