454-55-7

Basic information

• Product Name: 1-(trifluoromethyl)-1-cyclohexene
• Synonyms: 1-(trifluoromethyl)-1-cyclohexene
• CAS NO: 454-55-7
• Molecular Weight: 150.144
• Mol File: 454-55-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(trifluoromethyl)-1-cyclohexene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(trifluoromethyl)-1-cyclohexene(454-55-7)
• EPA Substance Registry System: 1-(trifluoromethyl)-1-cyclohexene(454-55-7)

Safety Data

• Hazardous Substances Data: 454-55-7(Hazardous Substances Data)

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 110-83-8 cyclohexene 
• 108-94-1 cyclohexanone 
• 17497-53-9 1-iodo-1-cyclohexene 
• 2314-97-8 iodotrifluoromethane 
• 28075-50-5 cyclohex-1-en-1-yl trifluoromethane sulfonate 
• 55106-53-1 1-bromocyclohexanecarboxylic acid 
• 950510-09-5 trimethyl((1-(trifluoromethyl)cyclohexyl)oxy)silane 
• 80768-55-4 1-(trifluoromethyl)-1-cyclohexanol 
• 89490-05-1 cyclohex-1-enylboronic acid 
• 2926-29-6 Langlois reagent 

Downstream Products

• 401-75-2 trifluoromethylcyclohexane 

Relevant articles and documents

TRPA1 ANTAGONISTS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH PAIN AND INFLAMMATION

The present invention is directed to compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions comprising said compounds,

The modified trifluoromethylation protocol applicable to electronically deficient iodopyridinones

Utilization of a mixed solvent system of DMF/HMPA=1/1 (v/v) to the KF/CuI/TMSCF3 reagent system proved to significantly affect the reaction, realizing convenient introduction of a trifluoromethyl (CF3) group not only to electron-deficient iodopyridinones with quite a few previous successful examples but also to aliphatic vinylic iodides.

Trifluoromethylation of alkenes by visible light photoredox catalysis

A method for trifluoromethylation of alkenes has been developed employing visible light photoredox catalysis with CF3I, Ru(Phen) 3Cl2, and DBU. This process works especially well for terminal alkenes to give alkenyl-CF3 products with only E-stereochemistry. The mild reaction conditions enable the trifluoromethylation of a range of alkenes that bear various functional groups.