80768-55-4Relevant articles and documents
TRPA1 ANTAGONISTS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH PAIN AND INFLAMMATION
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Page/Page column 28-29, (2021/11/26)
The present invention is directed to compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions comprising said compounds,
Sodium trifluoroacetate: An efficient precursor for the trifluoromethylation of aldehydes
Chang, Ying,Cai, Chun
, p. 3161 - 3164 (2007/10/03)
In a convenient and efficient procedure, the nucleophilic trifluoromethylation of aldehydes with sodium trifluoroacetate was achieved, using copper(I) halides as the catalyst.
Trifluoroacetamides from amino alcohols as nucleophilic trifluoromethylating reagents
Joubert, Jerome,Roussel, Solveig,Christophe, Carole,Billard, Thierry,Langlois, Bernard R.,Vidal, Thierry
, p. 3133 - 3136 (2007/10/03)
Both non-enolizable and enolizable carbonyl compounds underwent nucleophilic trifluoromethylation by a new family of cheap and efficient trifluoroacetamide reagents derived from vic-amino alcohols (see picture). From an ecological and an economic viewpoint these represent a promising alternative to other known trifluoromethylation reagents.