4541-73-5Relevant articles and documents
Silica sulfuric acid as a highly efficient catalyst for the synthesis of diarylacetic acids
Moore, Desiree L.,Denton, Allison E.,Kohinke, Rose M.,Craig, Brandon R.,Brenzovich, William E.
supporting information, p. 604 - 612 (2016/07/06)
ABSTRACT: An efficient heterogeneous method for the synthesis of diarylacetic acids was developed utilizing silica sulfuric acid as a catalyst. The reaction is highly efficient with a small amount of catalyst for the combination of a variety of electron-n
Palladium-catalyzed α-arylation of carboxylic acid derivatives with grignard reagent
Tanaka, Daiki,Tanaka, Shota,Mori, Atsunori
supporting information, p. 4254 - 4257 (2014/07/21)
The reaction of arylacetic acid with aryl halides in the presence of a palladium(0) catalyst proceeds with a Grignard reagent (2 equiv.) to afford diarylated acetic acids. Deprotonation was confirmed by treatment with allyl bromide, which revealed that th
A Study of the Ferrous Ion-initiated SRN1 Reactions of Halogenoarenes with tert-Butyl Acetate and N-Acylmorpholine Enolates
Leeuwen, Milko van,McKillop, Alexander
, p. 2433 - 2440 (2007/10/02)
A detailed preparative study is reported of the ferrous ion-initiated SRN1 reactions of a range of halogenoarenes with the sodium enolates of tert-butyl acetate, n-acetylmorpholine and a number of higher N-acylmorpholines.Smooth and rapid substitution occurs in many cases, and good to excellent yields were obtained of arylacetic esters or acids, arylacetamides and arylalkanamides.The broad scope and limitations of the process have been defined, and the possible role of the ferrous ion is discussed.