454221-08-0 Usage
Description
(-)-(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol, also known as levomethadone, is a chiral compound with a molecular formula of C15H25NO2. It is a tertiary amine and a secondary alcohol with a 3-methoxyphenyl group attached to the carbon atom. Levomethadone is a synthetic opioid analgesic used for the treatment of chronic pain and opioid addiction.
Used in Pharmaceutical Industry:
(-)-(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol is used as an analgesic for the treatment of chronic pain and opioid addiction. It acts on the central nervous system to produce pain relief and feelings of euphoria, and it is commonly used in clinical settings as a substitute for morphine in the treatment of severe pain.
Used in Clinical Settings:
(-)-(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol is used as a substitute for morphine in the treatment of severe pain. It provides effective pain relief while reducing the risk of dependence and addiction associated with morphine.
However, it is important to note that (-)-(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol also carries a high risk of dependence and addiction, and its use is strictly regulated to ensure patient safety and minimize the potential for misuse.
Check Digit Verification of cas no
The CAS Registry Mumber 454221-08-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,4,2,2 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 454221-08:
(8*4)+(7*5)+(6*4)+(5*2)+(4*2)+(3*1)+(2*0)+(1*8)=120
120 % 10 = 0
So 454221-08-0 is a valid CAS Registry Number.
454221-08-0Relevant articles and documents
A NOVEL STEREOSPECIFIC SYNTHESIS OF (-) (2S,3S)-1-DIMETHYLAMINO-3-(3-METHOXYPHENYL)-2-METHYL PENTAN-3-OL
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Page/Page column 9, (2012/08/08)
The present invention relates to a novel stereospecific synthesis of (-) (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl pentan-3-ol an intermediate in the synthesis of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol.
Separation of Stereoisomeric N,N-Dialkylamino-2Alkyl-3-Hydroxy-3-Phenylalkanes
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, (2008/12/04)
The invention concerns a method for the isolation of a stereoisomer from a mixture comprising the two stereoisomers of the general formulae (I-A) and (I-A′) and/or the two stereoisomers of the general formulae (I-B) and (I-B′) in which R1, R2 and R3, identical or different, are selected from the group consisting of —H, —F, —Cl, —C1-C6-alkyl, —S—C1-C6-alkyl, —OH, —O—C1-C6-alkyl, —O—C1-C6-alkylenephenyl, —OCO—C1-C6-alkyl, —OCON(C1-C6-alkyl)2 and —O—SiR8R9R10 (in which R8, R9 and R10, identical or different, are —C1-C6-alkyl or -phenyl);R4 is —H or —C1-C6-alkyl;R5 is —C1-C6-alkyl; andR6 and R7, identical or different, are —H or —C1-C6-alkyl; or their salts with organic or inorganic acids; comprising the step (a) manipulating the mixture ratio of the stereoisomers in the mixture so that at least one of the stereoisomers is present in an enantiomeric excess.
1-phenyl-3-dimethylaminopropane compounds with a pharmacological effect
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Example 2, (2010/01/30)
1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.
