51690-03-0

Basic information

• Product Name: 1-Dimethylamino-2-methylpentan-3-one
• Synonyms: 1-Dimethylamino-2-methylpentan-3-one;3-Pentanone,1-(diMethylaMino)-2-Methyl-;1-(dimethylamino)-2-methyl-3-pentanone
• CAS NO: 51690-03-0
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.23
• EINECS: 1806241-263-5
• Mol File: 51690-03-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 182.7 °C at 760 mmHg
• Flash Point: 48.8 °C
• Appearance: /
• Density: 0.866 g/cm³
• Vapor Pressure: 0.799mmHg at 25°C
• Refractive Index: 1.431
• Storage Temp.: 2-8°C
• PKA: 8.83±0.28(Predicted)
• CAS DataBase Reference: 1-Dimethylamino-2-methylpentan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Dimethylamino-2-methylpentan-3-one(51690-03-0)
• EPA Substance Registry System: 1-Dimethylamino-2-methylpentan-3-one(51690-03-0)

Safety Data

• Hazardous Substances Data: 51690-03-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 547, 1982 DOI: 10.1016/S0040-4039(00)86885-9

InChI:InChI=1/C8H17NO/c1-5-8(10)7(2)6-9(3)4/h7H,5-6H2,1-4H3

Upstream product

• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 96-22-0 pentan-3-one 
• 17510-47-3 3-trimethylsilyloxy-2-pentene 
• 25468-31-9 N-methyl-N-methylenemethanaminium 2,2,2-trifluoroacetate 
• 159144-11-3 (R)-1-(dimethylamino)-2-methylpentan-3-one 
• 159144-11-3 (2S)-1-(dimethylamino)-2-methylpentan-3-one 
• 51425-53-7 (E)-3-[(trimethylsilyl)oxy]pent-2-ene 
• 30354-18-8 N,N-dimethyl(methylene)ammonium chloride 
• 56275-84-4 N-(butoxymethyl)dimethylamine 
• 51-80-9 bis-(dimethylamino)methane 
• 78024-10-9 cis-(n-Bu)2BOC(Et)CHCH₃ 

Downstream Products

• 67960-99-0 6-Benzyl-3-ethyl-4-methyl-cyclohex-2-enon 
• 67960-98-9 4-Benzyl-2,3,6-trimethyl-cyclohex-2-enon 
• 433936-26-6 (2RS,3RS)-1-dimethylamino-2-methyl-3-(3-methylsulphanylphenyl)-pentan-3-ol Hydrochloride 
• 175590-75-7 1-dimethylamino-3-(3-methoxyphenyl)-2-methyl-3-pentanol hydrochloride 
• 175590-75-7 (2R,3R)/(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol hydrochloride 
• 175590-76-8 (2R,3S)-1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol 
• 809282-20-0 (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol 
• 454221-08-0 (-)-(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol 
• 433936-14-2 (+)-(2R,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol 
• 433936-25-5 (2RS,3RS)-3-(3,4-dichlorophenyl)-1-dimethylamino-2-methylpentan-3-ol Hydrochloride 
• 197145-32-7 (2RS,3RS)-3-(3-difluoromethyl-phenyl)-1-dimethylamino-2-methyl-pentan-3-ol hydrochloride 

Relevant articles and documents

A NOVEL STEREOSPECIFIC SYNTHESIS OF (-) (2S,3S)-1-DIMETHYLAMINO-3-(3-METHOXYPHENYL)-2-METHYL PENTAN-3-OL

The present invention relates to a novel stereospecific synthesis of (-) (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl pentan-3-ol an intermediate in the synthesis of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol.

Unique reactivity of aminoketones in the trifluoromethylation with trialkyl(trifluoromethyl)silanes

Aminoketones were trifluoromethylated by using trialkyl(trifluoromethyl) silanes without any reaction promoters. Formation of cyclic intermediates is proposed to be possible transition states in this reaction. Moderate diastereoselectivities were observed in the trifluoromethylation of the aminoketones having a side chain.

A Convenient Regioselective Synthesis of Mannich Bases

A new, convenient regioselective process for aminomethylation of ketones is reported, involving the in situ formation of silyl enol ethers and iminium salts.